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NO ASSOCIATION BETWEEN tHbmass AND POLYMORPHISMS IN THE HBB GENE IN ENDURANCE ATHLETES.

Malczewska-Lenczowska J, Orysiak J, Majorczyk E, Pokrywka A, Kaczmarski J, Szygula Z, Sitkowski D - Biol Sport (2014)

Bottom Line: No differences were found in the HBB genotype and allele frequencies between male and female athletes.Regardless of the polymorphisms, no relationships were found between HBB genotypes as well as alleles and relative values of tHbmass, expressed per body mass (g · kg(-1) BM), both in female and male athletes.It cannot be ruled out that several polymorphisms, each with a small but significant contribution, may be responsible for the amount of haemoglobin.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Physiology, Institute of Sport, Warsaw, Poland.

ABSTRACT
The aim of this study was to examine the association between tHbmass and HBB gene polymorphisms in athletes of endurance disciplines. Eighty-two well-trained athletes (female n=36, male n=46), aged 19.3 ± 2.7 years, representing cross country skiing (n=37) and middle- and long-distance running (n=45), participated in the study. Genotyping for 2 polymorphisms in the HBB gene (- 551C/T and intron 2, +16 C/G) was performed using restriction fragment length polymorphism analysis. Total haemoglobin mass (tHbmass) was determined by the optimized carbon monoxide rebreathing method. Blood morphology, indices of iron status (ferritin, transferrin receptor and total iron binding capacity) and C reactive protein were also determined. No differences were found in the HBB genotype and allele frequencies between male and female athletes. Regardless of the polymorphisms, no relationships were found between HBB genotypes as well as alleles and relative values of tHbmass, expressed per body mass (g · kg(-1) BM), both in female and male athletes. Our results demonstrated that -551 C/T and intron 2, +16 C/G polymorphisms of the HBB gene have no association with total haemoglobin mass in endurance athletes. It cannot be ruled out that several polymorphisms, each with a small but significant contribution, may be responsible for the amount of haemoglobin.

No MeSH data available.


Related in: MedlinePlus

RELATIVE THBMASS ACCORDING TO ALLELES OF -551C/T POLYMORPHISM OF HBB GENE IN MALE (UPPER) AND FEMALE (BOTTOM) ATHLETES
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Figure 0002: RELATIVE THBMASS ACCORDING TO ALLELES OF -551C/T POLYMORPHISM OF HBB GENE IN MALE (UPPER) AND FEMALE (BOTTOM) ATHLETES

Mentions: Both polymorphisms were in Hardy-Weinberg equilibrium in male and female athletes. No differences were found in the HBB genotype and allele frequencies between male and female athletes (Table 2). The HBB genotypes had no significant effect on relative values of tHbmass (Table 3). No relationships were found between HBB alleles in the case of both polymorphisms and relative values of tHbmass (Figures 1 and 2).


NO ASSOCIATION BETWEEN tHbmass AND POLYMORPHISMS IN THE HBB GENE IN ENDURANCE ATHLETES.

Malczewska-Lenczowska J, Orysiak J, Majorczyk E, Pokrywka A, Kaczmarski J, Szygula Z, Sitkowski D - Biol Sport (2014)

RELATIVE THBMASS ACCORDING TO ALLELES OF -551C/T POLYMORPHISM OF HBB GENE IN MALE (UPPER) AND FEMALE (BOTTOM) ATHLETES
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042665&req=5

Figure 0002: RELATIVE THBMASS ACCORDING TO ALLELES OF -551C/T POLYMORPHISM OF HBB GENE IN MALE (UPPER) AND FEMALE (BOTTOM) ATHLETES
Mentions: Both polymorphisms were in Hardy-Weinberg equilibrium in male and female athletes. No differences were found in the HBB genotype and allele frequencies between male and female athletes (Table 2). The HBB genotypes had no significant effect on relative values of tHbmass (Table 3). No relationships were found between HBB alleles in the case of both polymorphisms and relative values of tHbmass (Figures 1 and 2).

Bottom Line: No differences were found in the HBB genotype and allele frequencies between male and female athletes.Regardless of the polymorphisms, no relationships were found between HBB genotypes as well as alleles and relative values of tHbmass, expressed per body mass (g · kg(-1) BM), both in female and male athletes.It cannot be ruled out that several polymorphisms, each with a small but significant contribution, may be responsible for the amount of haemoglobin.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Physiology, Institute of Sport, Warsaw, Poland.

ABSTRACT
The aim of this study was to examine the association between tHbmass and HBB gene polymorphisms in athletes of endurance disciplines. Eighty-two well-trained athletes (female n=36, male n=46), aged 19.3 ± 2.7 years, representing cross country skiing (n=37) and middle- and long-distance running (n=45), participated in the study. Genotyping for 2 polymorphisms in the HBB gene (- 551C/T and intron 2, +16 C/G) was performed using restriction fragment length polymorphism analysis. Total haemoglobin mass (tHbmass) was determined by the optimized carbon monoxide rebreathing method. Blood morphology, indices of iron status (ferritin, transferrin receptor and total iron binding capacity) and C reactive protein were also determined. No differences were found in the HBB genotype and allele frequencies between male and female athletes. Regardless of the polymorphisms, no relationships were found between HBB genotypes as well as alleles and relative values of tHbmass, expressed per body mass (g · kg(-1) BM), both in female and male athletes. Our results demonstrated that -551 C/T and intron 2, +16 C/G polymorphisms of the HBB gene have no association with total haemoglobin mass in endurance athletes. It cannot be ruled out that several polymorphisms, each with a small but significant contribution, may be responsible for the amount of haemoglobin.

No MeSH data available.


Related in: MedlinePlus