Limits...
Endocrine response to an ultra-marathon in pre- and post-menopausal women.

Copeland JL, Verzosa ML - Biol Sport (2014)

Bottom Line: Total IGF-I decreased after the race (P < 0.01) and remained lower in recovery.Postmenopausal women had significantly lower estradiol at baseline, but there were no other group differences.Further research is needed to confirm the effect of these endocrine changes on health and performance.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Kinesiology, University of Lethbridge, 4401 University Drive, Lethbridge AB, Canada.

ABSTRACT
Ultra-endurance competitions are becoming increasingly popular but there is limited research on female participants. The purpose of this study was to examine changes in estrogen and the IGF-I system in women after an ultra-marathon. Six pairs of pre- and post- menopausal women were matched for race finish times;mean finish time was 20 hours. Blood samples were drawn 24 hours before the race, at the finish, and 24 hours into recovery. Samples were analysed for estradiol, total IGF-I, IGFBP-1, and intact IGFBP-3. There was a significant increase in estradiol following the race in both groups (P < 0.05). Total IGF-I decreased after the race (P < 0.01) and remained lower in recovery. IGFBP-1 increased after the race (P < 0.001) but returned to pre-race levels after 24 hours, while intact IGFBP-3 was significantly lower post-race and in recovery (P < 0.001). Postmenopausal women had significantly lower estradiol at baseline, but there were no other group differences. These results demonstrate that among recreational female runners, an ultra-marathon is associated with IGF system changes that are consistent with an energy-deficient, catabolic state. Further research is needed to confirm the effect of these endocrine changes on health and performance.

No MeSH data available.


Related in: MedlinePlus

SERUM ESTRADIOL CONCENTRATIONS BEFORE, AFTER, AND 24 HOURS AFTER AN ULTRA-MARATHON IN PRE- AND POST-MENOPAUSAL WOMEN.Note:Data are expressed as means ± SEM. Black bars and pre-race values, dark grey bars are immediately post-race values and light grey bars are 24 hour recovery values. † significantly different than pre-race value in post-menopausal women (P < 0.05). * significantly different than pre-race value (P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4042659&req=5

Figure 0001: SERUM ESTRADIOL CONCENTRATIONS BEFORE, AFTER, AND 24 HOURS AFTER AN ULTRA-MARATHON IN PRE- AND POST-MENOPAUSAL WOMEN.Note:Data are expressed as means ± SEM. Black bars and pre-race values, dark grey bars are immediately post-race values and light grey bars are 24 hour recovery values. † significantly different than pre-race value in post-menopausal women (P < 0.05). * significantly different than pre-race value (P < 0.05).

Mentions: Before the race, estradiol was significantly higher in the pre-menopausal women (P < 0.05). Estradiol increased, on average, 97% (139% with plasma volume correction) from pre-race to post-race (P < 0.05) (Figure 1), with 10 of the 12 participants having a greater than 10% increase and 9 of 12 having a greater than 50% increase (Figure 2). 24-hour recovery estradiol was not significantly different than pre-race or post-race samples. There was no significant group effect, however, there was a trend towards a significant group by time interaction (P = 0.09).


Endocrine response to an ultra-marathon in pre- and post-menopausal women.

Copeland JL, Verzosa ML - Biol Sport (2014)

SERUM ESTRADIOL CONCENTRATIONS BEFORE, AFTER, AND 24 HOURS AFTER AN ULTRA-MARATHON IN PRE- AND POST-MENOPAUSAL WOMEN.Note:Data are expressed as means ± SEM. Black bars and pre-race values, dark grey bars are immediately post-race values and light grey bars are 24 hour recovery values. † significantly different than pre-race value in post-menopausal women (P < 0.05). * significantly different than pre-race value (P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042659&req=5

Figure 0001: SERUM ESTRADIOL CONCENTRATIONS BEFORE, AFTER, AND 24 HOURS AFTER AN ULTRA-MARATHON IN PRE- AND POST-MENOPAUSAL WOMEN.Note:Data are expressed as means ± SEM. Black bars and pre-race values, dark grey bars are immediately post-race values and light grey bars are 24 hour recovery values. † significantly different than pre-race value in post-menopausal women (P < 0.05). * significantly different than pre-race value (P < 0.05).
Mentions: Before the race, estradiol was significantly higher in the pre-menopausal women (P < 0.05). Estradiol increased, on average, 97% (139% with plasma volume correction) from pre-race to post-race (P < 0.05) (Figure 1), with 10 of the 12 participants having a greater than 10% increase and 9 of 12 having a greater than 50% increase (Figure 2). 24-hour recovery estradiol was not significantly different than pre-race or post-race samples. There was no significant group effect, however, there was a trend towards a significant group by time interaction (P = 0.09).

Bottom Line: Total IGF-I decreased after the race (P < 0.01) and remained lower in recovery.Postmenopausal women had significantly lower estradiol at baseline, but there were no other group differences.Further research is needed to confirm the effect of these endocrine changes on health and performance.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Kinesiology, University of Lethbridge, 4401 University Drive, Lethbridge AB, Canada.

ABSTRACT
Ultra-endurance competitions are becoming increasingly popular but there is limited research on female participants. The purpose of this study was to examine changes in estrogen and the IGF-I system in women after an ultra-marathon. Six pairs of pre- and post- menopausal women were matched for race finish times;mean finish time was 20 hours. Blood samples were drawn 24 hours before the race, at the finish, and 24 hours into recovery. Samples were analysed for estradiol, total IGF-I, IGFBP-1, and intact IGFBP-3. There was a significant increase in estradiol following the race in both groups (P < 0.05). Total IGF-I decreased after the race (P < 0.01) and remained lower in recovery. IGFBP-1 increased after the race (P < 0.001) but returned to pre-race levels after 24 hours, while intact IGFBP-3 was significantly lower post-race and in recovery (P < 0.001). Postmenopausal women had significantly lower estradiol at baseline, but there were no other group differences. These results demonstrate that among recreational female runners, an ultra-marathon is associated with IGF system changes that are consistent with an energy-deficient, catabolic state. Further research is needed to confirm the effect of these endocrine changes on health and performance.

No MeSH data available.


Related in: MedlinePlus