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Extracellular volume fraction is associated with B-type natriuretic peptide in hypertrophic cardiomyopathy

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Hypertrophic cardiomyopathy is a common cardiovascular genetic disease characterized by sarcomeric gene mutations which lead to findings of cardiac hypertrophy, myocyte disarray, and fibrosis... While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) detects focal, macroscopic regions of replacement fibrosis non-invasively, novel T1 CMR measurement techniques including extracellular volume fraction (ECV) diffuse interstitial fibrosis throughout the myocardium... Given that such states may be associated with myocardial fibrosis, and because BNP levels provide independent prognostic insight in HCM, we sought to determine the association between BNP and ECV measurement by CMR... There was a moderate correlation (r = 0.58, p < 0.0001) between lnBNP and ECV (Figure 1)... ECV remained significantly associated with lnBNP after adjusting for LGE, LVOT obstruction, BMI, and LVM... When analyses were stratified by the presence or absence of LGE, ECV remained significantly associated with lnBNP (Table 1)... We found a novel association between lnBNP and ECV by CMR, after adjustment for confounding variables... The relationship persisted even after including LGE in regression models and stratifying by its presence... BNP and ECV are both strong predictors of adverse events... Detection of diffuse interstitial fibrosis by ECV may be a meaningful imaging biomarker to characterize HCM status, progression, and outcomes and warrants further study.

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Mentions: There was a moderate correlation (r = 0.58, p < 0.0001) between lnBNP and ECV (Figure 1). ECV remained significantly associated with lnBNP after adjusting for LGE, LVOT obstruction, BMI, and LVM. When analyses were stratified by the presence or absence of LGE, ECV remained significantly associated with lnBNP (Table 1).


Extracellular volume fraction is associated with B-type natriuretic peptide in hypertrophic cardiomyopathy
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
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getmorefigures.php?uid=PMC4042607&req=5

Mentions: There was a moderate correlation (r = 0.58, p < 0.0001) between lnBNP and ECV (Figure 1). ECV remained significantly associated with lnBNP after adjusting for LGE, LVOT obstruction, BMI, and LVM. When analyses were stratified by the presence or absence of LGE, ECV remained significantly associated with lnBNP (Table 1).

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Hypertrophic cardiomyopathy is a common cardiovascular genetic disease characterized by sarcomeric gene mutations which lead to findings of cardiac hypertrophy, myocyte disarray, and fibrosis... While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) detects focal, macroscopic regions of replacement fibrosis non-invasively, novel T1 CMR measurement techniques including extracellular volume fraction (ECV) diffuse interstitial fibrosis throughout the myocardium... Given that such states may be associated with myocardial fibrosis, and because BNP levels provide independent prognostic insight in HCM, we sought to determine the association between BNP and ECV measurement by CMR... There was a moderate correlation (r = 0.58, p < 0.0001) between lnBNP and ECV (Figure 1)... ECV remained significantly associated with lnBNP after adjusting for LGE, LVOT obstruction, BMI, and LVM... When analyses were stratified by the presence or absence of LGE, ECV remained significantly associated with lnBNP (Table 1)... We found a novel association between lnBNP and ECV by CMR, after adjustment for confounding variables... The relationship persisted even after including LGE in regression models and stratifying by its presence... BNP and ECV are both strong predictors of adverse events... Detection of diffuse interstitial fibrosis by ECV may be a meaningful imaging biomarker to characterize HCM status, progression, and outcomes and warrants further study.

No MeSH data available.