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Single sodium pyruvate ingestion modifies blood acid-base status and post-exercise lactate concentration in humans.

Olek RA, Kujach S, Wnuk D, Laskowski R - Nutrients (2014)

Bottom Line: Nine active, but non-specifically trained, male subjects participated in the double-blind, placebo-controlled, crossover study.The capillary blood samples were obtained at rest, 60 min after ingestion, and then three and 15 min after completing the workout protocol to analyze acid-base status and lactate, pyruvate, alanine, glucose concentrations.In conclusion, the sodium pyruvate ingestion one hour before workout modified the blood acid-base status and the lactate production during the exercise.

View Article: PubMed Central - PubMed

Affiliation: Biochemistry Department, Gdansk University of Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland. robol@awf.gda.pl.

ABSTRACT
This study examined the effect of a single sodium pyruvate ingestion on a blood acid-base status and exercise metabolism markers. Nine active, but non-specifically trained, male subjects participated in the double-blind, placebo-controlled, crossover study. One hour prior to the exercise, subjects ingested either 0.1 g·kg(-1) of body mass of a sodium pyruvate or placebo. The capillary blood samples were obtained at rest, 60 min after ingestion, and then three and 15 min after completing the workout protocol to analyze acid-base status and lactate, pyruvate, alanine, glucose concentrations. The pulmonary gas exchange, minute ventilation and the heart rate were measured during the exercise at a constant power output, corresponding to ~90% VO2max. The blood pH, bicarbonate and the base excess were significantly higher after sodium pyruvate ingestion than in the placebo trial. The blood lactate concentration was not different after the ingestion, but the post-exercise was significantly higher in the pyruvate trial (12.9 ± 0.9 mM) than in the placebo trial (10.6 ± 0.3 mM, p < 0.05) and remained elevated (nonsignificant) after 15 min of recovery. The blood pyruvate, alanine and glucose concentrations, as well as the overall pulmonary gas exchange during the exercise were not affected by the pyruvate ingestion. In conclusion, the sodium pyruvate ingestion one hour before workout modified the blood acid-base status and the lactate production during the exercise.

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Blood lactate (LA) measured before placebo (●) and NaP (○) ingestion (Pre-Ing.), 60 min after ingestion (Post-Ing.), 3 min after completion of exercise (Post-Ex.), and 15 min of recovery (15-Post). Values are the means ± SEM. * Significantly different from placebo at the same time point (p < 0.05).
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nutrients-06-01981-f002: Blood lactate (LA) measured before placebo (●) and NaP (○) ingestion (Pre-Ing.), 60 min after ingestion (Post-Ing.), 3 min after completion of exercise (Post-Ex.), and 15 min of recovery (15-Post). Values are the means ± SEM. * Significantly different from placebo at the same time point (p < 0.05).

Mentions: Blood LA concentration was not different after ingestion, but post-exercise was significantly higher in the NaP (12.9 ± 0.9 mM) than in the placebo (10.6 ± 0.3 mM, p < 0.05) and remained elevated (nonsignificant) after 15 min of recovery (Figure 2).


Single sodium pyruvate ingestion modifies blood acid-base status and post-exercise lactate concentration in humans.

Olek RA, Kujach S, Wnuk D, Laskowski R - Nutrients (2014)

Blood lactate (LA) measured before placebo (●) and NaP (○) ingestion (Pre-Ing.), 60 min after ingestion (Post-Ing.), 3 min after completion of exercise (Post-Ex.), and 15 min of recovery (15-Post). Values are the means ± SEM. * Significantly different from placebo at the same time point (p < 0.05).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042581&req=5

nutrients-06-01981-f002: Blood lactate (LA) measured before placebo (●) and NaP (○) ingestion (Pre-Ing.), 60 min after ingestion (Post-Ing.), 3 min after completion of exercise (Post-Ex.), and 15 min of recovery (15-Post). Values are the means ± SEM. * Significantly different from placebo at the same time point (p < 0.05).
Mentions: Blood LA concentration was not different after ingestion, but post-exercise was significantly higher in the NaP (12.9 ± 0.9 mM) than in the placebo (10.6 ± 0.3 mM, p < 0.05) and remained elevated (nonsignificant) after 15 min of recovery (Figure 2).

Bottom Line: Nine active, but non-specifically trained, male subjects participated in the double-blind, placebo-controlled, crossover study.The capillary blood samples were obtained at rest, 60 min after ingestion, and then three and 15 min after completing the workout protocol to analyze acid-base status and lactate, pyruvate, alanine, glucose concentrations.In conclusion, the sodium pyruvate ingestion one hour before workout modified the blood acid-base status and the lactate production during the exercise.

View Article: PubMed Central - PubMed

Affiliation: Biochemistry Department, Gdansk University of Physical Education and Sport, Gorskiego 1, 80-336 Gdansk, Poland. robol@awf.gda.pl.

ABSTRACT
This study examined the effect of a single sodium pyruvate ingestion on a blood acid-base status and exercise metabolism markers. Nine active, but non-specifically trained, male subjects participated in the double-blind, placebo-controlled, crossover study. One hour prior to the exercise, subjects ingested either 0.1 g·kg(-1) of body mass of a sodium pyruvate or placebo. The capillary blood samples were obtained at rest, 60 min after ingestion, and then three and 15 min after completing the workout protocol to analyze acid-base status and lactate, pyruvate, alanine, glucose concentrations. The pulmonary gas exchange, minute ventilation and the heart rate were measured during the exercise at a constant power output, corresponding to ~90% VO2max. The blood pH, bicarbonate and the base excess were significantly higher after sodium pyruvate ingestion than in the placebo trial. The blood lactate concentration was not different after the ingestion, but the post-exercise was significantly higher in the pyruvate trial (12.9 ± 0.9 mM) than in the placebo trial (10.6 ± 0.3 mM, p < 0.05) and remained elevated (nonsignificant) after 15 min of recovery. The blood pyruvate, alanine and glucose concentrations, as well as the overall pulmonary gas exchange during the exercise were not affected by the pyruvate ingestion. In conclusion, the sodium pyruvate ingestion one hour before workout modified the blood acid-base status and the lactate production during the exercise.

Show MeSH
Related in: MedlinePlus