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Relationship between erythrocyte omega-3 content and obesity is gender dependent.

Howe PR, Buckley JD, Murphy KJ, Pettman T, Milte C, Coates AM - Nutrients (2014)

Bottom Line: Both DHA and EPA + DHA correlated inversely with BMI, WC and BF in women while DPA correlated inversely with BF in men.Quartile distributions and curvilinear regression of the Omega-3 Index versus BMI revealed a steep rise of BMI in the lower range of the Omega-3 Index in women, but no association in men.Thus the results highlight important gender differences in relationships of specific LC n-3 PUFA in erythrocytes to markers of adiposity.

View Article: PubMed Central - PubMed

Affiliation: Nutritional Physiology Research Centre, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. peter.howe@newcastle.edu.au.

ABSTRACT
Epidemiological evidence of an inverse association between consumption of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) and obesity has been conflicting, even though studies in animal models of obesity and limited human trials suggest that LC n-3 PUFA consumption may contribute to weight loss. We used baseline data from a convenience sample of 476 adults (291 women, 185 men) participating in clinical trials at our Centre to explore relationships between erythrocyte levels of LC n-3 PUFA (a reliable indicator of habitual intake) and measures of adiposity, viz. body mass index (BMI), waist circumference (WC) and body fat (BF) assessed by dual-energy X-ray absorptiometry. Means ± SD of assessments were BMI: 34 ± 7 and 31 ± 5 kg/m2; WC: 105 ± 16 and 110 ± 13 cm; BF: 48 ± 5 and 35% ± 6% in women and men respectively. Erythrocyte levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were similar in men and women while docosapentaenoic acid (DPA) was higher and EPA + DHA (Omega-3 Index) slightly lower in men than in women. Both DHA and EPA + DHA correlated inversely with BMI, WC and BF in women while DPA correlated inversely with BF in men. Quartile distributions and curvilinear regression of the Omega-3 Index versus BMI revealed a steep rise of BMI in the lower range of the Omega-3 Index in women, but no association in men. Thus the results highlight important gender differences in relationships of specific LC n-3 PUFA in erythrocytes to markers of adiposity. If these reflect causal relationships between LC n-3 PUFA consumption and risk of obesity, gender specific targeted interventions should be considered.

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Average BMI values in quartiles of the Omega-3 Index.
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nutrients-06-01850-f001: Average BMI values in quartiles of the Omega-3 Index.

Mentions: BMI is the most widely used measure of obesity and the Omega-3 Index is the most widely accepted marker of habitual intake of LC n-3 PUFA. Hence it was of interest to further illustrate the relationship between these measures. Figure 1 shows the mean values for BMI in each quartile of the Omega-3 Index for each gender. The lack of a significant relationship in men was apparent. It was also apparent that the relationship between the Omega-3 Index and BMI in women was not linear. BMI values appeared to rise steeply in the lower quartiles of the Omega-3 Index. There were highly significant differences between mean BMI in the lowest quartile and mean BMI in the two highest quartiles of the Omega-3 Index in women.


Relationship between erythrocyte omega-3 content and obesity is gender dependent.

Howe PR, Buckley JD, Murphy KJ, Pettman T, Milte C, Coates AM - Nutrients (2014)

Average BMI values in quartiles of the Omega-3 Index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042576&req=5

nutrients-06-01850-f001: Average BMI values in quartiles of the Omega-3 Index.
Mentions: BMI is the most widely used measure of obesity and the Omega-3 Index is the most widely accepted marker of habitual intake of LC n-3 PUFA. Hence it was of interest to further illustrate the relationship between these measures. Figure 1 shows the mean values for BMI in each quartile of the Omega-3 Index for each gender. The lack of a significant relationship in men was apparent. It was also apparent that the relationship between the Omega-3 Index and BMI in women was not linear. BMI values appeared to rise steeply in the lower quartiles of the Omega-3 Index. There were highly significant differences between mean BMI in the lowest quartile and mean BMI in the two highest quartiles of the Omega-3 Index in women.

Bottom Line: Both DHA and EPA + DHA correlated inversely with BMI, WC and BF in women while DPA correlated inversely with BF in men.Quartile distributions and curvilinear regression of the Omega-3 Index versus BMI revealed a steep rise of BMI in the lower range of the Omega-3 Index in women, but no association in men.Thus the results highlight important gender differences in relationships of specific LC n-3 PUFA in erythrocytes to markers of adiposity.

View Article: PubMed Central - PubMed

Affiliation: Nutritional Physiology Research Centre, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. peter.howe@newcastle.edu.au.

ABSTRACT
Epidemiological evidence of an inverse association between consumption of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) and obesity has been conflicting, even though studies in animal models of obesity and limited human trials suggest that LC n-3 PUFA consumption may contribute to weight loss. We used baseline data from a convenience sample of 476 adults (291 women, 185 men) participating in clinical trials at our Centre to explore relationships between erythrocyte levels of LC n-3 PUFA (a reliable indicator of habitual intake) and measures of adiposity, viz. body mass index (BMI), waist circumference (WC) and body fat (BF) assessed by dual-energy X-ray absorptiometry. Means ± SD of assessments were BMI: 34 ± 7 and 31 ± 5 kg/m2; WC: 105 ± 16 and 110 ± 13 cm; BF: 48 ± 5 and 35% ± 6% in women and men respectively. Erythrocyte levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were similar in men and women while docosapentaenoic acid (DPA) was higher and EPA + DHA (Omega-3 Index) slightly lower in men than in women. Both DHA and EPA + DHA correlated inversely with BMI, WC and BF in women while DPA correlated inversely with BF in men. Quartile distributions and curvilinear regression of the Omega-3 Index versus BMI revealed a steep rise of BMI in the lower range of the Omega-3 Index in women, but no association in men. Thus the results highlight important gender differences in relationships of specific LC n-3 PUFA in erythrocytes to markers of adiposity. If these reflect causal relationships between LC n-3 PUFA consumption and risk of obesity, gender specific targeted interventions should be considered.

Show MeSH
Related in: MedlinePlus