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Red ginseng treatment for two weeks promotes fat metabolism during exercise in mice.

Hwang H, Kim J, Park J, Yun H, Cheon WK, Kim B, Lee CH, Suh H, Lim K - Nutrients (2014)

Bottom Line: All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group).Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week.The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise; These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Nutrition, Department of Physical Education, Konkuk University, Seoul 120, Neungdong-ro, Gwangin-gu, Seoul 143-701, Korea. hfilm@konkuk.ac.kr.

ABSTRACT

Purpose: Red ginseng (RG) has been reported to improve the blood and organ lipid profile when combined with exercise. However, the effect of RG on energy metabolism during exercise is poorly understood. Therefore, this study was designed to investigate whether RG treatment alters fat utilization during exercise;

Methods: We used seven-week-old ICR mice (n = 42). RG (1 g/kg) was administered orally daily during two weeks of endurance training. All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group). Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week. After a two-week experimental period, we measured substrate utilization during exercise at the same intensity and duration of training using a respiratory calorimetry chamber. Mice were dissected for glycogen measurement of muscles and liver before, immediately after, and one hour after the exercise;

Result: Fat oxidation during the initial 20 min of the one-hour exercise significantly increased in the RG group compared to the CON group. In addition, the liver glycogen stores significantly decreased immediately after the one-hour exercise compared to at rest in the RG group, but did not differ between immediately after the one-hour exercise and at rest in the RG group. The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise;

Conclusions: These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise. This might lead to a delay in peripheral fatigue during endurance exercise performance.

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The change in plasma parameters during exercise and after exercise for one hour. (A): Glucose; (B): Insulin; (C): Free fatty acid level at rest, after exercise, and recovery in the CON and RG groups. Values are presented as means ± standard error (n = 14). # vs. Rest in RG p < 0.05; ** vs. After exercise in RG, p < 0.05; * vs. Rest in CON, p < 0.01; § vs. After exercise in CON, p < 0.01; CON: no treatment with training; RG: RG treatment with training.
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nutrients-06-01874-f002: The change in plasma parameters during exercise and after exercise for one hour. (A): Glucose; (B): Insulin; (C): Free fatty acid level at rest, after exercise, and recovery in the CON and RG groups. Values are presented as means ± standard error (n = 14). # vs. Rest in RG p < 0.05; ** vs. After exercise in RG, p < 0.05; * vs. Rest in CON, p < 0.01; § vs. After exercise in CON, p < 0.01; CON: no treatment with training; RG: RG treatment with training.

Mentions: The plasma concentrations of glucose and insulin did not differ between the groups at any time point (Figure 2A,B). The plasma concentrations of FFA decreased after recovery from the exercise for 1 h in both groups, but it did not differ between the groups at any time point (Figure 2C).


Red ginseng treatment for two weeks promotes fat metabolism during exercise in mice.

Hwang H, Kim J, Park J, Yun H, Cheon WK, Kim B, Lee CH, Suh H, Lim K - Nutrients (2014)

The change in plasma parameters during exercise and after exercise for one hour. (A): Glucose; (B): Insulin; (C): Free fatty acid level at rest, after exercise, and recovery in the CON and RG groups. Values are presented as means ± standard error (n = 14). # vs. Rest in RG p < 0.05; ** vs. After exercise in RG, p < 0.05; * vs. Rest in CON, p < 0.01; § vs. After exercise in CON, p < 0.01; CON: no treatment with training; RG: RG treatment with training.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042568&req=5

nutrients-06-01874-f002: The change in plasma parameters during exercise and after exercise for one hour. (A): Glucose; (B): Insulin; (C): Free fatty acid level at rest, after exercise, and recovery in the CON and RG groups. Values are presented as means ± standard error (n = 14). # vs. Rest in RG p < 0.05; ** vs. After exercise in RG, p < 0.05; * vs. Rest in CON, p < 0.01; § vs. After exercise in CON, p < 0.01; CON: no treatment with training; RG: RG treatment with training.
Mentions: The plasma concentrations of glucose and insulin did not differ between the groups at any time point (Figure 2A,B). The plasma concentrations of FFA decreased after recovery from the exercise for 1 h in both groups, but it did not differ between the groups at any time point (Figure 2C).

Bottom Line: All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group).Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week.The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise; These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Nutrition, Department of Physical Education, Konkuk University, Seoul 120, Neungdong-ro, Gwangin-gu, Seoul 143-701, Korea. hfilm@konkuk.ac.kr.

ABSTRACT

Purpose: Red ginseng (RG) has been reported to improve the blood and organ lipid profile when combined with exercise. However, the effect of RG on energy metabolism during exercise is poorly understood. Therefore, this study was designed to investigate whether RG treatment alters fat utilization during exercise;

Methods: We used seven-week-old ICR mice (n = 42). RG (1 g/kg) was administered orally daily during two weeks of endurance training. All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group). Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week. After a two-week experimental period, we measured substrate utilization during exercise at the same intensity and duration of training using a respiratory calorimetry chamber. Mice were dissected for glycogen measurement of muscles and liver before, immediately after, and one hour after the exercise;

Result: Fat oxidation during the initial 20 min of the one-hour exercise significantly increased in the RG group compared to the CON group. In addition, the liver glycogen stores significantly decreased immediately after the one-hour exercise compared to at rest in the RG group, but did not differ between immediately after the one-hour exercise and at rest in the RG group. The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise;

Conclusions: These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise. This might lead to a delay in peripheral fatigue during endurance exercise performance.

Show MeSH
Related in: MedlinePlus