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Red ginseng treatment for two weeks promotes fat metabolism during exercise in mice.

Hwang H, Kim J, Park J, Yun H, Cheon WK, Kim B, Lee CH, Suh H, Lim K - Nutrients (2014)

Bottom Line: All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group).Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week.The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise; These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Nutrition, Department of Physical Education, Konkuk University, Seoul 120, Neungdong-ro, Gwangin-gu, Seoul 143-701, Korea. hfilm@konkuk.ac.kr.

ABSTRACT

Purpose: Red ginseng (RG) has been reported to improve the blood and organ lipid profile when combined with exercise. However, the effect of RG on energy metabolism during exercise is poorly understood. Therefore, this study was designed to investigate whether RG treatment alters fat utilization during exercise;

Methods: We used seven-week-old ICR mice (n = 42). RG (1 g/kg) was administered orally daily during two weeks of endurance training. All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group). Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week. After a two-week experimental period, we measured substrate utilization during exercise at the same intensity and duration of training using a respiratory calorimetry chamber. Mice were dissected for glycogen measurement of muscles and liver before, immediately after, and one hour after the exercise;

Result: Fat oxidation during the initial 20 min of the one-hour exercise significantly increased in the RG group compared to the CON group. In addition, the liver glycogen stores significantly decreased immediately after the one-hour exercise compared to at rest in the RG group, but did not differ between immediately after the one-hour exercise and at rest in the RG group. The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise;

Conclusions: These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise. This might lead to a delay in peripheral fatigue during endurance exercise performance.

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The change in carbohydrate oxidation and fat oxidation during exercise for 1 h. (A). The change in carbohydrate oxidation during exercise for 1 h; (B). The change in fat oxidation during exercise for 1 h; (C). Fat oxidation at every 20 min. Values are presented as means ± standard error (n = 21). * vs. CON p < 0.05; CON: no treatment with training, RG: RG treatment with training.
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nutrients-06-01874-f001: The change in carbohydrate oxidation and fat oxidation during exercise for 1 h. (A). The change in carbohydrate oxidation during exercise for 1 h; (B). The change in fat oxidation during exercise for 1 h; (C). Fat oxidation at every 20 min. Values are presented as means ± standard error (n = 21). * vs. CON p < 0.05; CON: no treatment with training, RG: RG treatment with training.

Mentions: The exercise lasted for one hour at an intensity of about 65%–75% . After the two-week experimental period, carbohydrate oxidation during exercise was not different between the two groups (Figure 1A). In addition, after the experimental period, fat oxidation during exercise was not different between the two groups (Figure 1B). In contrast, when examining each session of exercise separately, fat oxidation during the initial 20 min of the one-hour exercise was significantly higher in the RG group (35.5 ± 0.8 mg/kg/min) than in the CON group (30.5 ± 1.5 mg/kg/min) (Figure 1C).


Red ginseng treatment for two weeks promotes fat metabolism during exercise in mice.

Hwang H, Kim J, Park J, Yun H, Cheon WK, Kim B, Lee CH, Suh H, Lim K - Nutrients (2014)

The change in carbohydrate oxidation and fat oxidation during exercise for 1 h. (A). The change in carbohydrate oxidation during exercise for 1 h; (B). The change in fat oxidation during exercise for 1 h; (C). Fat oxidation at every 20 min. Values are presented as means ± standard error (n = 21). * vs. CON p < 0.05; CON: no treatment with training, RG: RG treatment with training.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042568&req=5

nutrients-06-01874-f001: The change in carbohydrate oxidation and fat oxidation during exercise for 1 h. (A). The change in carbohydrate oxidation during exercise for 1 h; (B). The change in fat oxidation during exercise for 1 h; (C). Fat oxidation at every 20 min. Values are presented as means ± standard error (n = 21). * vs. CON p < 0.05; CON: no treatment with training, RG: RG treatment with training.
Mentions: The exercise lasted for one hour at an intensity of about 65%–75% . After the two-week experimental period, carbohydrate oxidation during exercise was not different between the two groups (Figure 1A). In addition, after the experimental period, fat oxidation during exercise was not different between the two groups (Figure 1B). In contrast, when examining each session of exercise separately, fat oxidation during the initial 20 min of the one-hour exercise was significantly higher in the RG group (35.5 ± 0.8 mg/kg/min) than in the CON group (30.5 ± 1.5 mg/kg/min) (Figure 1C).

Bottom Line: All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group).Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week.The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise; These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Nutrition, Department of Physical Education, Konkuk University, Seoul 120, Neungdong-ro, Gwangin-gu, Seoul 143-701, Korea. hfilm@konkuk.ac.kr.

ABSTRACT

Purpose: Red ginseng (RG) has been reported to improve the blood and organ lipid profile when combined with exercise. However, the effect of RG on energy metabolism during exercise is poorly understood. Therefore, this study was designed to investigate whether RG treatment alters fat utilization during exercise;

Methods: We used seven-week-old ICR mice (n = 42). RG (1 g/kg) was administered orally daily during two weeks of endurance training. All mice were randomized into two groups: training only group (CON group) and training with RG group (RG group). Endurance training consisted of 20~25 m/min on a slope of 8° for one hour five times a week. After a two-week experimental period, we measured substrate utilization during exercise at the same intensity and duration of training using a respiratory calorimetry chamber. Mice were dissected for glycogen measurement of muscles and liver before, immediately after, and one hour after the exercise;

Result: Fat oxidation during the initial 20 min of the one-hour exercise significantly increased in the RG group compared to the CON group. In addition, the liver glycogen stores significantly decreased immediately after the one-hour exercise compared to at rest in the RG group, but did not differ between immediately after the one-hour exercise and at rest in the RG group. The glycogen concentration in white and red gastrocnemius muscle did not differ between the groups immediately after the one-hour exercise;

Conclusions: These results suggest that RG treatment for two weeks promotes fat oxidation and a glycogen-sparing effect during exercise. This might lead to a delay in peripheral fatigue during endurance exercise performance.

Show MeSH
Related in: MedlinePlus