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Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.

Monteiro EM, Chibli LA, Yamamoto CH, Pereira MC, Vilela FM, Rodarte MP, Pinto MA, do Amaral Mda P, Silvério MS, Araújo AL, de Araújo Ada L, Del-Vechio-Vieira G, de Sousa OV - Nutrients (2014)

Bottom Line: The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg.The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin.These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. erikahenriques07@yahoo.com.br.

ABSTRACT
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

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Effects of the sesame oil and sesamin on the latency time of mice exposed to the hot plate test. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** P < 0.001 vs. control group.
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nutrients-06-01931-f003: Effects of the sesame oil and sesamin on the latency time of mice exposed to the hot plate test. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** P < 0.001 vs. control group.

Mentions: Considering the result observed in the first phase of the formalin test, we decided to evaluate the oil using hot plate method, an important assay of central antinociceptive activity investigation. The effect of the oil from S. indicum and sesamin in the hot plate test varied according to the doses and the time of observation (Figure 3). At times 0 and 30 min, no significant antinociceptive effect was observed, while at time 60 min, the doses of 200 and 400 mg/kg of the oil and 200 mg/kg of sesamin increased significantly the latency time. After 90 min of treatment, the doses 200 and 400 mg/kg of the oil (23.96% and 55.47%; p < 0.01 and p < 0.001, respectively) and 200 mg/kg of sesamin (31.80%; p < 0.001) increased the reaction time. The procedure was also performed in the presence of naloxone, an opioid antagonist. It was observed that the naloxone was able to inhibit the antinociceptive effects of sesamin and morphine, but was not able to inhibit the effect of the S. indicum oil.


Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.

Monteiro EM, Chibli LA, Yamamoto CH, Pereira MC, Vilela FM, Rodarte MP, Pinto MA, do Amaral Mda P, Silvério MS, Araújo AL, de Araújo Ada L, Del-Vechio-Vieira G, de Sousa OV - Nutrients (2014)

Effects of the sesame oil and sesamin on the latency time of mice exposed to the hot plate test. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** P < 0.001 vs. control group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042560&req=5

nutrients-06-01931-f003: Effects of the sesame oil and sesamin on the latency time of mice exposed to the hot plate test. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** P < 0.001 vs. control group.
Mentions: Considering the result observed in the first phase of the formalin test, we decided to evaluate the oil using hot plate method, an important assay of central antinociceptive activity investigation. The effect of the oil from S. indicum and sesamin in the hot plate test varied according to the doses and the time of observation (Figure 3). At times 0 and 30 min, no significant antinociceptive effect was observed, while at time 60 min, the doses of 200 and 400 mg/kg of the oil and 200 mg/kg of sesamin increased significantly the latency time. After 90 min of treatment, the doses 200 and 400 mg/kg of the oil (23.96% and 55.47%; p < 0.01 and p < 0.001, respectively) and 200 mg/kg of sesamin (31.80%; p < 0.001) increased the reaction time. The procedure was also performed in the presence of naloxone, an opioid antagonist. It was observed that the naloxone was able to inhibit the antinociceptive effects of sesamin and morphine, but was not able to inhibit the effect of the S. indicum oil.

Bottom Line: The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg.The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin.These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. erikahenriques07@yahoo.com.br.

ABSTRACT
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

Show MeSH
Related in: MedlinePlus