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Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.

Monteiro EM, Chibli LA, Yamamoto CH, Pereira MC, Vilela FM, Rodarte MP, Pinto MA, do Amaral Mda P, Silvério MS, Araújo AL, de Araújo Ada L, Del-Vechio-Vieira G, de Sousa OV - Nutrients (2014)

Bottom Line: The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg.The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin.These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. erikahenriques07@yahoo.com.br.

ABSTRACT
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

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Related in: MedlinePlus

Effects of the sesame oil and sesamin on formalin-induced nociception in mice. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control group.
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nutrients-06-01931-f002: Effects of the sesame oil and sesamin on formalin-induced nociception in mice. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control group.

Mentions: The intraplantar injection of formalin promoted a biphasic characteristic response (Figure 2). The time spent licking in the first phase (0–5 min) was 86.25 ± 1.98 s and in the second phase (15–30 min) was 91.62 ± 1.89 s for the control group. After 60 min of treatment, a significant reduction in the licking time (p < 0.05 or p < 0.001) was observed during the first phase (neurogenic) by 10.01%, and 29.90% with 200 and 400 mg/kg of oil, respectively (Figure 2). In this phase, sesamin reduced the paw licking time by 24.13% at the dose of 200 mg/kg (p < 0.001). In the second phase, the doses of 200 and 400 mg/kg of oil also inhibited significantly (p < 0.01 or p < 0.001) at 13.50% and 31.67%, respectively, when compared to the control. In addition, sesamin produced a reduction of the second phase at 22.88% (100 mg/kg) and 35.76% (200 mg/kg). As expected, morphine (5 mg/kg, s.c.) significantly reduced the formalin response in both phases. However, indomethacin was active only in the second phase.


Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.

Monteiro EM, Chibli LA, Yamamoto CH, Pereira MC, Vilela FM, Rodarte MP, Pinto MA, do Amaral Mda P, Silvério MS, Araújo AL, de Araújo Ada L, Del-Vechio-Vieira G, de Sousa OV - Nutrients (2014)

Effects of the sesame oil and sesamin on formalin-induced nociception in mice. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4042560&req=5

nutrients-06-01931-f002: Effects of the sesame oil and sesamin on formalin-induced nociception in mice. Data are mean ± S.E.M. of 8 mice. * p < 0.05; ** p < 0.01; *** p < 0.001 vs. control group.
Mentions: The intraplantar injection of formalin promoted a biphasic characteristic response (Figure 2). The time spent licking in the first phase (0–5 min) was 86.25 ± 1.98 s and in the second phase (15–30 min) was 91.62 ± 1.89 s for the control group. After 60 min of treatment, a significant reduction in the licking time (p < 0.05 or p < 0.001) was observed during the first phase (neurogenic) by 10.01%, and 29.90% with 200 and 400 mg/kg of oil, respectively (Figure 2). In this phase, sesamin reduced the paw licking time by 24.13% at the dose of 200 mg/kg (p < 0.001). In the second phase, the doses of 200 and 400 mg/kg of oil also inhibited significantly (p < 0.01 or p < 0.001) at 13.50% and 31.67%, respectively, when compared to the control. In addition, sesamin produced a reduction of the second phase at 22.88% (100 mg/kg) and 35.76% (200 mg/kg). As expected, morphine (5 mg/kg, s.c.) significantly reduced the formalin response in both phases. However, indomethacin was active only in the second phase.

Bottom Line: The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg.The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin.These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

View Article: PubMed Central - PubMed

Affiliation: Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil. erikahenriques07@yahoo.com.br.

ABSTRACT
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

Show MeSH
Related in: MedlinePlus