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Evaluation of the DDSolver software applications.

Zuo J, Gao Y, Bou-Chacra N, Löbenberg R - Biomed Res Int (2014)

Bottom Line: The results of the DDSolver analysis were compared with those obtained using an Excel worksheet.Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet.The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.

ABSTRACT
When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver analysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained similarity factors (f 2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver and Excel were used to calculate the release exponent "n" in the Korsmeyer-Peppas model. Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

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Example DDSolver report of model selection.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig5: Example DDSolver report of model selection.

Mentions: Outputs of DDSolver are displayed for each analysis as text and graphic mode in Microsoft Excel dataset or as text only in Word which is very convenient for the user because it can be incorporated in customized reports. The copies of DDSolver reports of a spreadsheet for profile comparison and model selection are shown in Figures 4 and 5, respectively.


Evaluation of the DDSolver software applications.

Zuo J, Gao Y, Bou-Chacra N, Löbenberg R - Biomed Res Int (2014)

Example DDSolver report of model selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4022259&req=5

fig5: Example DDSolver report of model selection.
Mentions: Outputs of DDSolver are displayed for each analysis as text and graphic mode in Microsoft Excel dataset or as text only in Word which is very convenient for the user because it can be incorporated in customized reports. The copies of DDSolver reports of a spreadsheet for profile comparison and model selection are shown in Figures 4 and 5, respectively.

Bottom Line: The results of the DDSolver analysis were compared with those obtained using an Excel worksheet.Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet.The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.

ABSTRACT
When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver analysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained similarity factors (f 2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver and Excel were used to calculate the release exponent "n" in the Korsmeyer-Peppas model. Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

Show MeSH