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Evaluation of the DDSolver software applications.

Zuo J, Gao Y, Bou-Chacra N, Löbenberg R - Biomed Res Int (2014)

Bottom Line: The results of the DDSolver analysis were compared with those obtained using an Excel worksheet.Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet.The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.

ABSTRACT
When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver analysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained similarity factors (f 2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver and Excel were used to calculate the release exponent "n" in the Korsmeyer-Peppas model. Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

Show MeSH
Dissolution profiles of three 250 mg amoxicillin products in simulated intestinal fluid before or after sample correction.
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Related In: Results  -  Collection


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fig2: Dissolution profiles of three 250 mg amoxicillin products in simulated intestinal fluid before or after sample correction.

Mentions: The data used to evaluate the dissolution profiles were obtained from the dissolution study of three different 250 mg amoxicillin capsules purchased from China, which are labeled A, B, and C. The test units were placed in a VK 7020 dissolution tester with six vessels, a VK 8000 autosampler station (Agilent Technologies, Carey, NC), and a USP apparatus 2. The Japanese Pharmacopeia Basket Sinkers (Quality Lab Accessories, Brigewater, NJ) which are compliant with USP were utilized. In the dissolution process, 1.25 mL sample was collected at 10, 15, 20, 30, 45, and 60 min without sample replacement from a 900 mL receptacle volume, respectively. The profiles after sample correction are shown in Figure 1 and used for profile comparison. Figure 2 shows profiles in the presences and absences of sample correction.


Evaluation of the DDSolver software applications.

Zuo J, Gao Y, Bou-Chacra N, Löbenberg R - Biomed Res Int (2014)

Dissolution profiles of three 250 mg amoxicillin products in simulated intestinal fluid before or after sample correction.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4022259&req=5

fig2: Dissolution profiles of three 250 mg amoxicillin products in simulated intestinal fluid before or after sample correction.
Mentions: The data used to evaluate the dissolution profiles were obtained from the dissolution study of three different 250 mg amoxicillin capsules purchased from China, which are labeled A, B, and C. The test units were placed in a VK 7020 dissolution tester with six vessels, a VK 8000 autosampler station (Agilent Technologies, Carey, NC), and a USP apparatus 2. The Japanese Pharmacopeia Basket Sinkers (Quality Lab Accessories, Brigewater, NJ) which are compliant with USP were utilized. In the dissolution process, 1.25 mL sample was collected at 10, 15, 20, 30, 45, and 60 min without sample replacement from a 900 mL receptacle volume, respectively. The profiles after sample correction are shown in Figure 1 and used for profile comparison. Figure 2 shows profiles in the presences and absences of sample correction.

Bottom Line: The results of the DDSolver analysis were compared with those obtained using an Excel worksheet.Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet.The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E1.

ABSTRACT
When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern. This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments. The data used in this report were chosen from two dissolution studies. The results of the DDSolver analysis were compared with those obtained using an Excel worksheet. The comparisons among three different products obtained similarity factors (f 2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet. The results differed when DDSolver and Excel were used to calculate the release exponent "n" in the Korsmeyer-Peppas model. Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet. The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.

Show MeSH