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Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly.

Arosio B, D'Addario C, Gussago C, Casati M, Tedone E, Ferri E, Nicolini P, Rossi PD, Maccarrone M, Mari D - Biomed Res Int (2014)

Bottom Line: The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression.Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context.Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS).

View Article: PubMed Central - PubMed

Affiliation: Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy ; Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy.

ABSTRACT
The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression. Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection. Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context. Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS). In this review, we address the role of biomarkers in AD with a focus on the notion that PBMCs may serve as a peripheral laboratory to find molecular signatures that could aid in differential diagnosis with other forms of dementia and in monitoring of disease progression.

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Related in: MedlinePlus

Scatter dot plots showing the distributions of molecular and biochemical parameters of PBMCs from controls (CT) and LOAD: activity (a), Ser16 phosphorylation (b), methylation (c), and gene expression (d). The lines across the boxes indicate median values.
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Related In: Results  -  Collection


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fig2: Scatter dot plots showing the distributions of molecular and biochemical parameters of PBMCs from controls (CT) and LOAD: activity (a), Ser16 phosphorylation (b), methylation (c), and gene expression (d). The lines across the boxes indicate median values.

Mentions: We have also shown that in LOAD subjects Ser16 phosphorylation levels of Pin1 were lower than in controls (Figure 2).


Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly.

Arosio B, D'Addario C, Gussago C, Casati M, Tedone E, Ferri E, Nicolini P, Rossi PD, Maccarrone M, Mari D - Biomed Res Int (2014)

Scatter dot plots showing the distributions of molecular and biochemical parameters of PBMCs from controls (CT) and LOAD: activity (a), Ser16 phosphorylation (b), methylation (c), and gene expression (d). The lines across the boxes indicate median values.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4022117&req=5

fig2: Scatter dot plots showing the distributions of molecular and biochemical parameters of PBMCs from controls (CT) and LOAD: activity (a), Ser16 phosphorylation (b), methylation (c), and gene expression (d). The lines across the boxes indicate median values.
Mentions: We have also shown that in LOAD subjects Ser16 phosphorylation levels of Pin1 were lower than in controls (Figure 2).

Bottom Line: The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression.Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context.Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS).

View Article: PubMed Central - PubMed

Affiliation: Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy ; Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy.

ABSTRACT
The steady and dramatic increase in the incidence of Alzheimer's disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression. Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection. Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context. Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS). In this review, we address the role of biomarkers in AD with a focus on the notion that PBMCs may serve as a peripheral laboratory to find molecular signatures that could aid in differential diagnosis with other forms of dementia and in monitoring of disease progression.

Show MeSH
Related in: MedlinePlus