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Mannan-binding lectin in cardiovascular disease.

Pągowska-Klimek I, Cedzyński M - Biomed Res Int (2014)

Bottom Line: Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well.The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors.That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a "double-edge sword," sometimes beneficial and, at other times disastrous for the host.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Intensive Care, Polish Mother's Memorial Hospital Institute, Rzgowska 281/289, 93-338 Łódź, Poland.

ABSTRACT
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a "double-edge sword," sometimes beneficial and, at other times disastrous for the host.

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Related in: MedlinePlus

Schematic overview of MBL-dependent activation of the lectin pathway of complement. Modified from [5]. Scheme of MBL-MASP complex based on [23].
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Related In: Results  -  Collection


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fig1: Schematic overview of MBL-dependent activation of the lectin pathway of complement. Modified from [5]. Scheme of MBL-MASP complex based on [23].

Mentions: MASP-2 is believed to be the key enzyme responsible for LP activation as its proteolytic activity against C4 and C2 significantly exceeds the activity of C1s, the corresponding element of the classical pathway [4, 19, 22]. MASP-1 was believed to upregulate lectin pathway activation. However, recently, its crucial role in MASP-2 activation has been postulated [23–25]. MASP-3 and nonenzymatic proteins are believed to play a regulatory role in this process [19, 26–28]. A schematic overview of LP activation is presented in Figure 1.


Mannan-binding lectin in cardiovascular disease.

Pągowska-Klimek I, Cedzyński M - Biomed Res Int (2014)

Schematic overview of MBL-dependent activation of the lectin pathway of complement. Modified from [5]. Scheme of MBL-MASP complex based on [23].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4022110&req=5

fig1: Schematic overview of MBL-dependent activation of the lectin pathway of complement. Modified from [5]. Scheme of MBL-MASP complex based on [23].
Mentions: MASP-2 is believed to be the key enzyme responsible for LP activation as its proteolytic activity against C4 and C2 significantly exceeds the activity of C1s, the corresponding element of the classical pathway [4, 19, 22]. MASP-1 was believed to upregulate lectin pathway activation. However, recently, its crucial role in MASP-2 activation has been postulated [23–25]. MASP-3 and nonenzymatic proteins are believed to play a regulatory role in this process [19, 26–28]. A schematic overview of LP activation is presented in Figure 1.

Bottom Line: Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well.The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors.That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a "double-edge sword," sometimes beneficial and, at other times disastrous for the host.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Intensive Care, Polish Mother's Memorial Hospital Institute, Rzgowska 281/289, 93-338 Łódź, Poland.

ABSTRACT
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms. Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well. This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease. MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation. The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors. That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a "double-edge sword," sometimes beneficial and, at other times disastrous for the host.

Show MeSH
Related in: MedlinePlus