A clinical frailty index in aging mice: comparisons with frailty index data in humans.
Bottom Line: FIs calculated with the original performance-based eight-item FI increased from 0.06 ± 0.01 at 5 months to 0.36 ± 0.06 at 19 months and 0.38 ± 0.04 at 28 months (n = 14).By contrast, the increase was graded with a 31-item clinical FI (0.02 ± 0.005 at 5 months; 0.12 ± 0.008 at 19 months; 0.33 ± 0.02 at 28 months; n = 14).FI scores calculated from 70 self-report items from the first wave of the Survey of Health, Ageing and Retirement in Europe were plotted as function of age (n = 30,025 people).
Affiliation: Department of Pharmacology.Show MeSH
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Mentions: To compare the relationship between the performance-based eight-item frailty index and the clinical frailty index, we plotted the scores for the eight-item index against those for the clinical index as shown in Figure 4A. The relationship between these two indices was generally linear although the data were not a good fit to a straight line (r2 = .43; p = .01; Figure 4A).