A clinical frailty index in aging mice: comparisons with frailty index data in humans.
Bottom Line: FIs calculated with the original performance-based eight-item FI increased from 0.06 ± 0.01 at 5 months to 0.36 ± 0.06 at 19 months and 0.38 ± 0.04 at 28 months (n = 14).By contrast, the increase was graded with a 31-item clinical FI (0.02 ± 0.005 at 5 months; 0.12 ± 0.008 at 19 months; 0.33 ± 0.02 at 28 months; n = 14).FI scores calculated from 70 self-report items from the first wave of the Survey of Health, Ageing and Retirement in Europe were plotted as function of age (n = 30,025 people).
Affiliation: Department of Pharmacology.Show MeSH
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Mentions: To illustrate the relationship between age and mortality in our colony of C57BL/6J female mice, a Kaplan–Meier survival curve was constructed (Figure 1). Mortality occurred when animals either died unexpectedly or were euthanized due to illness. At the start of this investigation, the young adult mice used in this study were 161 days old (~5 months; n = 5), the older adult group was 566 days old (~19 months; n = 4), and the aged group was 839 days old (~28 months; n = 5). The ages of the mice used at the start of this study are indicated on the survival curve (Figure 1; n = 293 female mice).