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A clinical frailty index in aging mice: comparisons with frailty index data in humans.

Whitehead JC, Hildebrand BA, Sun M, Rockwood MR, Rose RA, Rockwood K, Howlett SE - J. Gerontol. A Biol. Sci. Med. Sci. (2013)

Bottom Line: FIs calculated with the original performance-based eight-item FI increased from 0.06 ± 0.01 at 5 months to 0.36 ± 0.06 at 19 months and 0.38 ± 0.04 at 28 months (n = 14).By contrast, the increase was graded with a 31-item clinical FI (0.02 ± 0.005 at 5 months; 0.12 ± 0.008 at 19 months; 0.33 ± 0.02 at 28 months; n = 14).FI scores calculated from 70 self-report items from the first wave of the Survey of Health, Ageing and Retirement in Europe were plotted as function of age (n = 30,025 people).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology.

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Kaplan–Meier survival curve for mortality in C57BL/6J female mice. Mice were aged in the Carlton Animal Care Facility at Dalhousie University. Mortality occurred when mice died unexpectedly or were euthanized due to illness. The ages of mice used in the present study are indicated (n = 293 female mice).
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Figure 1: Kaplan–Meier survival curve for mortality in C57BL/6J female mice. Mice were aged in the Carlton Animal Care Facility at Dalhousie University. Mortality occurred when mice died unexpectedly or were euthanized due to illness. The ages of mice used in the present study are indicated (n = 293 female mice).

Mentions: To illustrate the relationship between age and mortality in our colony of C57BL/6J female mice, a Kaplan–Meier survival curve was constructed (Figure 1). Mortality occurred when animals either died unexpectedly or were euthanized due to illness. At the start of this investigation, the young adult mice used in this study were 161 days old (~5 months; n = 5), the older adult group was 566 days old (~19 months; n = 4), and the aged group was 839 days old (~28 months; n = 5). The ages of the mice used at the start of this study are indicated on the survival curve (Figure 1; n = 293 female mice).


A clinical frailty index in aging mice: comparisons with frailty index data in humans.

Whitehead JC, Hildebrand BA, Sun M, Rockwood MR, Rose RA, Rockwood K, Howlett SE - J. Gerontol. A Biol. Sci. Med. Sci. (2013)

Kaplan–Meier survival curve for mortality in C57BL/6J female mice. Mice were aged in the Carlton Animal Care Facility at Dalhousie University. Mortality occurred when mice died unexpectedly or were euthanized due to illness. The ages of mice used in the present study are indicated (n = 293 female mice).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4022099&req=5

Figure 1: Kaplan–Meier survival curve for mortality in C57BL/6J female mice. Mice were aged in the Carlton Animal Care Facility at Dalhousie University. Mortality occurred when mice died unexpectedly or were euthanized due to illness. The ages of mice used in the present study are indicated (n = 293 female mice).
Mentions: To illustrate the relationship between age and mortality in our colony of C57BL/6J female mice, a Kaplan–Meier survival curve was constructed (Figure 1). Mortality occurred when animals either died unexpectedly or were euthanized due to illness. At the start of this investigation, the young adult mice used in this study were 161 days old (~5 months; n = 5), the older adult group was 566 days old (~19 months; n = 4), and the aged group was 839 days old (~28 months; n = 5). The ages of the mice used at the start of this study are indicated on the survival curve (Figure 1; n = 293 female mice).

Bottom Line: FIs calculated with the original performance-based eight-item FI increased from 0.06 ± 0.01 at 5 months to 0.36 ± 0.06 at 19 months and 0.38 ± 0.04 at 28 months (n = 14).By contrast, the increase was graded with a 31-item clinical FI (0.02 ± 0.005 at 5 months; 0.12 ± 0.008 at 19 months; 0.33 ± 0.02 at 28 months; n = 14).FI scores calculated from 70 self-report items from the first wave of the Survey of Health, Ageing and Retirement in Europe were plotted as function of age (n = 30,025 people).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology.

Show MeSH