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The role of dendritic cells in tissue-specific autoimmunity.

Mbongue J, Nicholas D, Firek A, Langridge W - J Immunol Res (2014)

Bottom Line: In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases.Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented.Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.

View Article: PubMed Central - PubMed

Affiliation: Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.

ABSTRACT
In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented. Further, we compare tissue specific to systemic autoimmunity to demonstrate how development of dendritic cell-based therapies may be broadly applicable to both classes of autoimmunity. Continued development of these research areas will lead us closer to clinical assessment of novel immunosuppressive therapy for the reversal and prevention of tissue-specific autoimmunity. Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.

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Potential mechanisms responsible for dendritic cell-mediated suppression of autoimmunity. (Left) Therapeutic strategies for DC-mediated therapy for tissue-specific autoimmunity. (Center) Molecular interactions by which these therapeutic strategies may function to suppress autoimmunity. (Right) Immune cell outcomes following the therapy that may stimulate immunological tolerance.
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fig2: Potential mechanisms responsible for dendritic cell-mediated suppression of autoimmunity. (Left) Therapeutic strategies for DC-mediated therapy for tissue-specific autoimmunity. (Center) Molecular interactions by which these therapeutic strategies may function to suppress autoimmunity. (Right) Immune cell outcomes following the therapy that may stimulate immunological tolerance.

Mentions: A variety of molecular and cellular strategies for suppression of tissue-specific autoimmunity are currently under development (Figure 2). These strategies include agonist or antagonist mediated interactions, pharmaceuticals, cytokine targeted antibody therapies, and immunosuppressive vaccines. Mechanisms by which DCs may be able to mediate the suppression of tissue-specific autoimmunity are discussed below.


The role of dendritic cells in tissue-specific autoimmunity.

Mbongue J, Nicholas D, Firek A, Langridge W - J Immunol Res (2014)

Potential mechanisms responsible for dendritic cell-mediated suppression of autoimmunity. (Left) Therapeutic strategies for DC-mediated therapy for tissue-specific autoimmunity. (Center) Molecular interactions by which these therapeutic strategies may function to suppress autoimmunity. (Right) Immune cell outcomes following the therapy that may stimulate immunological tolerance.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4022068&req=5

fig2: Potential mechanisms responsible for dendritic cell-mediated suppression of autoimmunity. (Left) Therapeutic strategies for DC-mediated therapy for tissue-specific autoimmunity. (Center) Molecular interactions by which these therapeutic strategies may function to suppress autoimmunity. (Right) Immune cell outcomes following the therapy that may stimulate immunological tolerance.
Mentions: A variety of molecular and cellular strategies for suppression of tissue-specific autoimmunity are currently under development (Figure 2). These strategies include agonist or antagonist mediated interactions, pharmaceuticals, cytokine targeted antibody therapies, and immunosuppressive vaccines. Mechanisms by which DCs may be able to mediate the suppression of tissue-specific autoimmunity are discussed below.

Bottom Line: In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases.Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented.Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.

View Article: PubMed Central - PubMed

Affiliation: Center for Health Disparities and Molecular Medicine, 11085 Campus Street, Mortensen Hall, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA.

ABSTRACT
In this review, we explore the role of dendritic cell subsets in the development of tissue-specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is becoming clear that we are only at the beginning of understanding the role of these antigen presenting cells in mediating autoimmunity. Emerging research areas for the study of dendritic cell involvement in the onset and inhibition of tissue-specific autoimmunity are presented. Further, we compare tissue specific to systemic autoimmunity to demonstrate how development of dendritic cell-based therapies may be broadly applicable to both classes of autoimmunity. Continued development of these research areas will lead us closer to clinical assessment of novel immunosuppressive therapy for the reversal and prevention of tissue-specific autoimmunity. Through description of dendritic cell functions in the modulation of tissue-specific autoimmunity, we hope to stimulate a greater appreciation and understanding of the role dendritic cells play in the development and treatment of autoimmunity.

Show MeSH
Related in: MedlinePlus