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Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials.

Dombrowski SU, Knittle K, Avenell A, Araújo-Soares V, Sniehotta FF - BMJ (2014)

Bottom Line: Orlistat combined with behavioural interventions resulted in a -1.80 kg (-2.54 to -1.06; eight comparisons, 1738 participants) difference compared with placebo at 12 months.All orlistat studies reported higher frequencies of adverse gastrointestinal events in the experimental compared with placebo control groups.A dose-response relation for orlistat treatment was found, with 120 mg doses three times a day leading to greater weight loss maintenance (-2.34 kg, -3.03 to -1.65) compared with 60 mg and 30 mg three times a day (-0.70 kg, 95% confidence interval -1.92 to 0.52), P=0.02.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK School of Natural Sciences, University of Stirling, Cottrell Building, Stirling FK9 4LA, UK.

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Fig 3 Mean difference in weight change at 12 months after initial weight loss in behavioural/lifestyle studies. BC=behaviour therapy + post-treatment therapy contact condition; BCA=behaviour therapy + post-treatment therapy contact + aerobic exercise maintenance condition; BCAS=behaviour therapy + post treatment therapy contact + aerobic exercise maintenance + social influence maintenance programme condition; F2F=face to face condition, FIPS=frequent in-person support condition; MIPS=minimal in-person support condition; Int=internet condition; PST=problem solving therapy condition; RPT=relapse prevention training condition; SF=skill focus condition, phone=telephone condition; WF=weight focus condition
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fig3: Fig 3 Mean difference in weight change at 12 months after initial weight loss in behavioural/lifestyle studies. BC=behaviour therapy + post-treatment therapy contact condition; BCA=behaviour therapy + post-treatment therapy contact + aerobic exercise maintenance condition; BCAS=behaviour therapy + post treatment therapy contact + aerobic exercise maintenance + social influence maintenance programme condition; F2F=face to face condition, FIPS=frequent in-person support condition; MIPS=minimal in-person support condition; Int=internet condition; PST=problem solving therapy condition; RPT=relapse prevention training condition; SF=skill focus condition, phone=telephone condition; WF=weight focus condition

Mentions: At 12 months, 15 behavioural/lifestyle studies including 25 comparisons202324363839404142434445464748 showed a mean difference in weight change of −1.56 kg (95% confidence interval −2.27 to −0.86 kg; I2=36%; fig 3).


Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials.

Dombrowski SU, Knittle K, Avenell A, Araújo-Soares V, Sniehotta FF - BMJ (2014)

Fig 3 Mean difference in weight change at 12 months after initial weight loss in behavioural/lifestyle studies. BC=behaviour therapy + post-treatment therapy contact condition; BCA=behaviour therapy + post-treatment therapy contact + aerobic exercise maintenance condition; BCAS=behaviour therapy + post treatment therapy contact + aerobic exercise maintenance + social influence maintenance programme condition; F2F=face to face condition, FIPS=frequent in-person support condition; MIPS=minimal in-person support condition; Int=internet condition; PST=problem solving therapy condition; RPT=relapse prevention training condition; SF=skill focus condition, phone=telephone condition; WF=weight focus condition
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4020585&req=5

fig3: Fig 3 Mean difference in weight change at 12 months after initial weight loss in behavioural/lifestyle studies. BC=behaviour therapy + post-treatment therapy contact condition; BCA=behaviour therapy + post-treatment therapy contact + aerobic exercise maintenance condition; BCAS=behaviour therapy + post treatment therapy contact + aerobic exercise maintenance + social influence maintenance programme condition; F2F=face to face condition, FIPS=frequent in-person support condition; MIPS=minimal in-person support condition; Int=internet condition; PST=problem solving therapy condition; RPT=relapse prevention training condition; SF=skill focus condition, phone=telephone condition; WF=weight focus condition
Mentions: At 12 months, 15 behavioural/lifestyle studies including 25 comparisons202324363839404142434445464748 showed a mean difference in weight change of −1.56 kg (95% confidence interval −2.27 to −0.86 kg; I2=36%; fig 3).

Bottom Line: Orlistat combined with behavioural interventions resulted in a -1.80 kg (-2.54 to -1.06; eight comparisons, 1738 participants) difference compared with placebo at 12 months.All orlistat studies reported higher frequencies of adverse gastrointestinal events in the experimental compared with placebo control groups.A dose-response relation for orlistat treatment was found, with 120 mg doses three times a day leading to greater weight loss maintenance (-2.34 kg, -3.03 to -1.65) compared with 60 mg and 30 mg three times a day (-0.70 kg, 95% confidence interval -1.92 to 0.52), P=0.02.

View Article: PubMed Central - PubMed

Affiliation: Institute of Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK School of Natural Sciences, University of Stirling, Cottrell Building, Stirling FK9 4LA, UK.

Show MeSH
Related in: MedlinePlus