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A mathematical model of the immune and neuroendocrine systems mutual regulation under the technogenic chemical factors impact.

Zaitseva NV, Kiryanov DA, Lanin DV, Chigvintsev VM - Comput Math Methods Med (2014)

Bottom Line: The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted.Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known.This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.

View Article: PubMed Central - PubMed

Affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.

ABSTRACT
The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.

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A chart of evolution of impairment of the bone marrow function to produce monocytes due to natural aging and under additional impact of technogenic chemical factors with a specification of scenario levels.
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fig2: A chart of evolution of impairment of the bone marrow function to produce monocytes due to natural aging and under additional impact of technogenic chemical factors with a specification of scenario levels.

Mentions: The identified parameters allow us to carry out a numerical experiment showing the behaviour of the obtained model under various scenario conditions which are understood to be various stages of functional disorders in the production of cells or regulatory molecules associated with the impacts of negative chemical factors. The model of impaired synthetic function of the studied organs determines the influence of several factors the major ones of which are chemical substances entering the human body from the environment. One of the possible solutions of (8) is given in Figure 2. The bone marrow has been chosen as an example producing organ as the core element of all the immune responses in the described example is monocytes/macrophages produced by this organ.


A mathematical model of the immune and neuroendocrine systems mutual regulation under the technogenic chemical factors impact.

Zaitseva NV, Kiryanov DA, Lanin DV, Chigvintsev VM - Comput Math Methods Med (2014)

A chart of evolution of impairment of the bone marrow function to produce monocytes due to natural aging and under additional impact of technogenic chemical factors with a specification of scenario levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020569&req=5

fig2: A chart of evolution of impairment of the bone marrow function to produce monocytes due to natural aging and under additional impact of technogenic chemical factors with a specification of scenario levels.
Mentions: The identified parameters allow us to carry out a numerical experiment showing the behaviour of the obtained model under various scenario conditions which are understood to be various stages of functional disorders in the production of cells or regulatory molecules associated with the impacts of negative chemical factors. The model of impaired synthetic function of the studied organs determines the influence of several factors the major ones of which are chemical substances entering the human body from the environment. One of the possible solutions of (8) is given in Figure 2. The bone marrow has been chosen as an example producing organ as the core element of all the immune responses in the described example is monocytes/macrophages produced by this organ.

Bottom Line: The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted.Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known.This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.

View Article: PubMed Central - PubMed

Affiliation: Federal Budget Scientific Institution, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm 614000, Russia.

ABSTRACT
The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.

Show MeSH
Related in: MedlinePlus