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Biomarkers of mercury exposure in the Amazon.

de Castro NS, Lima Mde O - Biomed Res Int (2014)

Bottom Line: Few studies have focused on the discovery of mercury biomarkers in the region's population.In this way, some studies have used genetics as well as immunological and cytogenetic tools in order to find a molecular biomarker for assessing the toxicological effect of mercury in the Amazonian population.Here we introduce the general aspects involved with each biomarker that was studied in the region in order to contextualize the reader and add information about the Amazonian life style and health that may be considered for future studies.

View Article: PubMed Central - PubMed

Affiliation: Evandro Chagas Institute (IEC), Health Surveillance Secretariat (SVS), 660990 Belém do Pará, PA, Brazil.

ABSTRACT
Mercury exposure in the Amazon has been studied since the 1980s decade and the assessment of human mercury exposure in the Amazon is difficult given that the natural occurrence of this metal is high and the concentration of mercury in biological samples of this population exceeds the standardized value of normality established by WHO. Few studies have focused on the discovery of mercury biomarkers in the region's population. In this way, some studies have used genetics as well as immunological and cytogenetic tools in order to find a molecular biomarker for assessing the toxicological effect of mercury in the Amazonian population. Most of those studies focused attention on the relation between mercury exposure and autoimmunity and, because of that, they will be discussed in more detail. Here we introduce the general aspects involved with each biomarker that was studied in the region in order to contextualize the reader and add information about the Amazonian life style and health that may be considered for future studies. We hope that, in the future, the toxicological studies in this field use high technological tools, such as the next generation sequencing and proteomics skills, in order to comprehend basic questions regarding the metabolic route of mercury in populations that are under constant exposure, such as in the Amazon.

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Related in: MedlinePlus

Map showing the locations where the studies about the association between mercury and immunological imbalance were performed.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Map showing the locations where the studies about the association between mercury and immunological imbalance were performed.

Mentions: The studies cited above covered eleven cities in the Brazilian Amazon (Figure 2) and gave a picture of the immunological status of some populations that presented different habits of fish intake, occupational activity, and environmental pressure. Thus, they highlighted the necessity for an application of a more comprehensive study about the immunological status of Amazonian population and opened new clues of the influence of malaria infection into immunological dysfunction.


Biomarkers of mercury exposure in the Amazon.

de Castro NS, Lima Mde O - Biomed Res Int (2014)

Map showing the locations where the studies about the association between mercury and immunological imbalance were performed.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020561&req=5

fig2: Map showing the locations where the studies about the association between mercury and immunological imbalance were performed.
Mentions: The studies cited above covered eleven cities in the Brazilian Amazon (Figure 2) and gave a picture of the immunological status of some populations that presented different habits of fish intake, occupational activity, and environmental pressure. Thus, they highlighted the necessity for an application of a more comprehensive study about the immunological status of Amazonian population and opened new clues of the influence of malaria infection into immunological dysfunction.

Bottom Line: Few studies have focused on the discovery of mercury biomarkers in the region's population.In this way, some studies have used genetics as well as immunological and cytogenetic tools in order to find a molecular biomarker for assessing the toxicological effect of mercury in the Amazonian population.Here we introduce the general aspects involved with each biomarker that was studied in the region in order to contextualize the reader and add information about the Amazonian life style and health that may be considered for future studies.

View Article: PubMed Central - PubMed

Affiliation: Evandro Chagas Institute (IEC), Health Surveillance Secretariat (SVS), 660990 Belém do Pará, PA, Brazil.

ABSTRACT
Mercury exposure in the Amazon has been studied since the 1980s decade and the assessment of human mercury exposure in the Amazon is difficult given that the natural occurrence of this metal is high and the concentration of mercury in biological samples of this population exceeds the standardized value of normality established by WHO. Few studies have focused on the discovery of mercury biomarkers in the region's population. In this way, some studies have used genetics as well as immunological and cytogenetic tools in order to find a molecular biomarker for assessing the toxicological effect of mercury in the Amazonian population. Most of those studies focused attention on the relation between mercury exposure and autoimmunity and, because of that, they will be discussed in more detail. Here we introduce the general aspects involved with each biomarker that was studied in the region in order to contextualize the reader and add information about the Amazonian life style and health that may be considered for future studies. We hope that, in the future, the toxicological studies in this field use high technological tools, such as the next generation sequencing and proteomics skills, in order to comprehend basic questions regarding the metabolic route of mercury in populations that are under constant exposure, such as in the Amazon.

Show MeSH
Related in: MedlinePlus