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Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

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Related in: MedlinePlus

FleXScan purely spatial analysis for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains seven South Florida (SF) counties including Miami-Dade, Palm Beach, Broward, Okeechobee, Monroe, Polk, and Glades (relative risk = 1.14, P value = 0.001). Secondary cluster found in Santa Rosa and Okaloosa counties (relative risk 1.77, P value = 0.001). Note that this differs from SaTScan analysis because the scanning window in FleXScan can vary in shape, whereas SaTScan is either circular or elliptical.
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fig4: FleXScan purely spatial analysis for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains seven South Florida (SF) counties including Miami-Dade, Palm Beach, Broward, Okeechobee, Monroe, Polk, and Glades (relative risk = 1.14, P value = 0.001). Secondary cluster found in Santa Rosa and Okaloosa counties (relative risk 1.77, P value = 0.001). Note that this differs from SaTScan analysis because the scanning window in FleXScan can vary in shape, whereas SaTScan is either circular or elliptical.

Mentions: The results with FleXScan differed slightly from those by SaTScan by including several counties in the “most likely cluster” that were not identified by SaTScan. In addition to Palm Beach, Broward, and Miami-Dade, FleXScan included the counties Okeechobee, Glades, Polk, and Martin in the cluster (Figure 4). FleXScan was not confined to circular shaped clusters, and the position of Lake Okeechobee in the southern part of Florida made it better to also use FleXScan. A secondary cluster was found in Santa Rosa and Okaloosa counties.


Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

FleXScan purely spatial analysis for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains seven South Florida (SF) counties including Miami-Dade, Palm Beach, Broward, Okeechobee, Monroe, Polk, and Glades (relative risk = 1.14, P value = 0.001). Secondary cluster found in Santa Rosa and Okaloosa counties (relative risk 1.77, P value = 0.001). Note that this differs from SaTScan analysis because the scanning window in FleXScan can vary in shape, whereas SaTScan is either circular or elliptical.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020503&req=5

fig4: FleXScan purely spatial analysis for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains seven South Florida (SF) counties including Miami-Dade, Palm Beach, Broward, Okeechobee, Monroe, Polk, and Glades (relative risk = 1.14, P value = 0.001). Secondary cluster found in Santa Rosa and Okaloosa counties (relative risk 1.77, P value = 0.001). Note that this differs from SaTScan analysis because the scanning window in FleXScan can vary in shape, whereas SaTScan is either circular or elliptical.
Mentions: The results with FleXScan differed slightly from those by SaTScan by including several counties in the “most likely cluster” that were not identified by SaTScan. In addition to Palm Beach, Broward, and Miami-Dade, FleXScan included the counties Okeechobee, Glades, Polk, and Martin in the cluster (Figure 4). FleXScan was not confined to circular shaped clusters, and the position of Lake Okeechobee in the southern part of Florida made it better to also use FleXScan. A secondary cluster was found in Santa Rosa and Okaloosa counties.

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

Show MeSH
Related in: MedlinePlus