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Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

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Related in: MedlinePlus

Increasing overall incidence of thyroid cancer in AYA 2000–2008.
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fig3: Increasing overall incidence of thyroid cancer in AYA 2000–2008.

Mentions: The above purely spatial analysis does not include time in the analysis. In order to provide information whether there was a specific time when the cluster occurred, the space-time function in SaTScan was employed. A statistically significant space-time cluster of thyroid cancer was found in SF from 2001 to 2003. The space-time permutation scan statistic which looks for space-time interaction clusters, adjusting for any purely spatial clusters as well as for any temporal trends, however, did not identify a surge in any given year for the period 2000–2008. Thus the observed space-time regional cluster seems to be due to an overall statewide increase in the thyroid cancer incidence rates, and thus the space-time findings are artifacts rather than true clusters. A time plot of age adjusted thyroid cancer incidence rates for 2000–2008 also supports the space-time permutation analysis with an increase in thyroid cancer cases statewide over time (Figure 3).


Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

Increasing overall incidence of thyroid cancer in AYA 2000–2008.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4020503&req=5

fig3: Increasing overall incidence of thyroid cancer in AYA 2000–2008.
Mentions: The above purely spatial analysis does not include time in the analysis. In order to provide information whether there was a specific time when the cluster occurred, the space-time function in SaTScan was employed. A statistically significant space-time cluster of thyroid cancer was found in SF from 2001 to 2003. The space-time permutation scan statistic which looks for space-time interaction clusters, adjusting for any purely spatial clusters as well as for any temporal trends, however, did not identify a surge in any given year for the period 2000–2008. Thus the observed space-time regional cluster seems to be due to an overall statewide increase in the thyroid cancer incidence rates, and thus the space-time findings are artifacts rather than true clusters. A time plot of age adjusted thyroid cancer incidence rates for 2000–2008 also supports the space-time permutation analysis with an increase in thyroid cancer cases statewide over time (Figure 3).

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

Show MeSH
Related in: MedlinePlus