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Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

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Related in: MedlinePlus

SaTScan purely spatial Poisson analysis for females, adjusted for age and race, for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains the South Florida (SF) counties of Miami-Dade and Broward (relative risk = 1.25, P value < 0.001). Secondary cluster is shown in simple hatched label and contains the northwest (NWF) county of Okaloosa (relative risk 1.88, P value = 0.003).
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fig2: SaTScan purely spatial Poisson analysis for females, adjusted for age and race, for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains the South Florida (SF) counties of Miami-Dade and Broward (relative risk = 1.25, P value < 0.001). Secondary cluster is shown in simple hatched label and contains the northwest (NWF) county of Okaloosa (relative risk 1.88, P value = 0.003).

Mentions: A separate analysis was run adjusted for age and sex but not for race. Identical clusters were identified as in the case when rates are adjusted for age, sex, and race. We conclude that race does not play an important role in creating the significant clusters. It is, however, also known that thyroid cancer in females has risen dramatically compared to males. So therefore further analysis was performed utilizing SatScan to determine if any spatial or space-time influences were detectable when analyzing the sexes separately. While the purely spatial analysis for thyroid rates (adjusted for age, sex, and race) resulted in two significant clusters (SF and NWF), when analyzing the data separately by sex, the female data set (adjusted for age and race) (Figure 2) identifies a smaller area of SF as the most likely cluster (P value = 0.001, RR = 1.25) and NWF as the secondary cluster (P value = 0.003, RR = 1.86). The purely spatial analysis of the male data also reveals a smaller but still separate part of SF as the most likely cluster (P value = 0.005, RR = 1.82). No other significant cluster exists for males.


Clusters of adolescent and young adult thyroid cancer in Florida counties.

Amin R, Burns JJ - Biomed Res Int (2014)

SaTScan purely spatial Poisson analysis for females, adjusted for age and race, for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains the South Florida (SF) counties of Miami-Dade and Broward (relative risk = 1.25, P value < 0.001). Secondary cluster is shown in simple hatched label and contains the northwest (NWF) county of Okaloosa (relative risk 1.88, P value = 0.003).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4020503&req=5

fig2: SaTScan purely spatial Poisson analysis for females, adjusted for age and race, for thyroid cancer in adolescents and young adults (AYA) 2000–2008. Primary cluster is shown in crosshatched label and contains the South Florida (SF) counties of Miami-Dade and Broward (relative risk = 1.25, P value < 0.001). Secondary cluster is shown in simple hatched label and contains the northwest (NWF) county of Okaloosa (relative risk 1.88, P value = 0.003).
Mentions: A separate analysis was run adjusted for age and sex but not for race. Identical clusters were identified as in the case when rates are adjusted for age, sex, and race. We conclude that race does not play an important role in creating the significant clusters. It is, however, also known that thyroid cancer in females has risen dramatically compared to males. So therefore further analysis was performed utilizing SatScan to determine if any spatial or space-time influences were detectable when analyzing the sexes separately. While the purely spatial analysis for thyroid rates (adjusted for age, sex, and race) resulted in two significant clusters (SF and NWF), when analyzing the data separately by sex, the female data set (adjusted for age and race) (Figure 2) identifies a smaller area of SF as the most likely cluster (P value = 0.001, RR = 1.25) and NWF as the secondary cluster (P value = 0.003, RR = 1.86). The purely spatial analysis of the male data also reveals a smaller but still separate part of SF as the most likely cluster (P value = 0.005, RR = 1.82). No other significant cluster exists for males.

Bottom Line: This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.These clusters persisted after controlling for demographics including sex, age, race.In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematics and Statistics, University of West Florida, Pensacola, FL 32514, USA.

ABSTRACT

Background: Thyroid cancer is a common cancer in adolescents and young adults ranking 4th in frequency. Thyroid cancer has captured the interest of epidemiologists because of its strong association to environmental factors. The goal of this study is to identify thyroid cancer clusters in Florida for the period 2000-2008. This will guide further discovery of potential risk factors within areas of the cluster compared to areas not in cluster.

Methods: Thyroid cancer cases for ages 15-39 were obtained from the Florida Cancer Data System. Next, using the purely spatial Poisson analysis function in SaTScan, the geographic distribution of thyroid cancer cases by county was assessed for clusters. The reference population was obtained from the Census Bureau 2010, which enabled controlling for population age, sex, and race.

Results: Two statistically significant clusters of thyroid cancer clusters were found in Florida: one in southern Florida (SF) (relative risk of 1.26; P value of <0.001) and the other in northwestern Florida (NWF) (relative risk of 1.71; P value of 0.012). These clusters persisted after controlling for demographics including sex, age, race.

Conclusion: In summary, we found evidence of thyroid cancer clustering in South Florida and North West Florida for adolescents and young adult.

Show MeSH
Related in: MedlinePlus