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Regional Cerebral Blood-Flow with 99mTc-ECD Brain Perfusion SPECT in Landau-Kleffner Syndrome: Report of Two Cases.

Nemati R, Nabipour I, Javadi H, Chabi N, Assadi M - Case Rep Radiol (2014)

Bottom Line: Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS.A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy.The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Bushehr Medical Center Hospital, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.

ABSTRACT
Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS. A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy. The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain. Overall, although asymmetrical temporoparietal perfusion appears as a common finding in LKS, SPECT findings in LKS alone cannot elucidate the pathogenic features of the disorder in the brain. Here, we present two cases of LKS in which we investigated SPECT perfusion scans.

No MeSH data available.


Related in: MedlinePlus

99mTc-ECD brain perfusion SPECT image of a 6-year-old boy with Landau-Kleffner syndrome (LKS). There is moderate hypoperfusion in the left temporal, left parietal, and left inferior frontal regions and also mild hypoperfusion in the right inferior parietal area. The upper rows indicate transverse 99mTc-ECD SPECT images. The middle rows indicate coronal 99mTc-ECD SPECT images. The lower rows indicate sagittal 99mTc-ECD SPECT images.
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fig2: 99mTc-ECD brain perfusion SPECT image of a 6-year-old boy with Landau-Kleffner syndrome (LKS). There is moderate hypoperfusion in the left temporal, left parietal, and left inferior frontal regions and also mild hypoperfusion in the right inferior parietal area. The upper rows indicate transverse 99mTc-ECD SPECT images. The middle rows indicate coronal 99mTc-ECD SPECT images. The lower rows indicate sagittal 99mTc-ECD SPECT images.

Mentions: A six-year-old right-handed male patient presented with normal early development of gross and fine motor skills, with normal early language development up to year 4. However, he developed a progressive receptive and expressive language disorder. He had no history of epilepsy, with the exception of one episode of a generalized tonic-clonic convulsion following a viral illness. His neurological examination was normal; and an EEG showed a spike and slow waves in both the right and left central regions. The cranial MRI was normal. A brain perfusion SPECT during the sleep state showed moderate decreased perfusion in the left temporal, left parietal, and left inferior frontal regions and mild hypoperfusion in the right inferior parietal area (Figure 2).


Regional Cerebral Blood-Flow with 99mTc-ECD Brain Perfusion SPECT in Landau-Kleffner Syndrome: Report of Two Cases.

Nemati R, Nabipour I, Javadi H, Chabi N, Assadi M - Case Rep Radiol (2014)

99mTc-ECD brain perfusion SPECT image of a 6-year-old boy with Landau-Kleffner syndrome (LKS). There is moderate hypoperfusion in the left temporal, left parietal, and left inferior frontal regions and also mild hypoperfusion in the right inferior parietal area. The upper rows indicate transverse 99mTc-ECD SPECT images. The middle rows indicate coronal 99mTc-ECD SPECT images. The lower rows indicate sagittal 99mTc-ECD SPECT images.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4020496&req=5

fig2: 99mTc-ECD brain perfusion SPECT image of a 6-year-old boy with Landau-Kleffner syndrome (LKS). There is moderate hypoperfusion in the left temporal, left parietal, and left inferior frontal regions and also mild hypoperfusion in the right inferior parietal area. The upper rows indicate transverse 99mTc-ECD SPECT images. The middle rows indicate coronal 99mTc-ECD SPECT images. The lower rows indicate sagittal 99mTc-ECD SPECT images.
Mentions: A six-year-old right-handed male patient presented with normal early development of gross and fine motor skills, with normal early language development up to year 4. However, he developed a progressive receptive and expressive language disorder. He had no history of epilepsy, with the exception of one episode of a generalized tonic-clonic convulsion following a viral illness. His neurological examination was normal; and an EEG showed a spike and slow waves in both the right and left central regions. The cranial MRI was normal. A brain perfusion SPECT during the sleep state showed moderate decreased perfusion in the left temporal, left parietal, and left inferior frontal regions and mild hypoperfusion in the right inferior parietal area (Figure 2).

Bottom Line: Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS.A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy.The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Bushehr Medical Center Hospital, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran.

ABSTRACT
Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS. A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy. The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain. Overall, although asymmetrical temporoparietal perfusion appears as a common finding in LKS, SPECT findings in LKS alone cannot elucidate the pathogenic features of the disorder in the brain. Here, we present two cases of LKS in which we investigated SPECT perfusion scans.

No MeSH data available.


Related in: MedlinePlus