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Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians.

Teo BW, Sabanayagam C, Liao J, Toh QC, Saw S, Wong TY, Sethi S - Int J Nephrol (2014)

Bottom Line: Results.Conclusions.Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, Singapore 119228.

ABSTRACT
Background. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may improve eGFR accuracy. We evaluated the new CKD-EPI equations incorporating cystatin C in a population of Asian Indians in classifying CKD across body mass index, diabetes, and hypertension status. Methods. We retrieved standardized serum creatinine and serum cystatin C data from a cohort of 2877 Asian Indians aged 40-80 years from the Singapore Indian Eye Study and calculated eGFR (in mL/min/1.73 m(2)) with the new CKD-EPI equations and serum creatinine only equation. Results. The creatinine only equation mean eGFR (88 ± 17) was similar to using spline Log cystatin C (88 ± 22). The lowest mean eGFR (81 ± 21) was obtained with the spline Log cystatin C-age, sex, and weight equation. The creatinine only equation had the fewest participants (7.1%) with eGFR <60 and spline Log cystatin C-age, sex, and weight equation had the most (16.1%). Conclusions. Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.

No MeSH data available.


Related in: MedlinePlus

Performance of estimating equations by age, gender, BMI, and diabetes status. Referent equation: serum creatinine 2009 equation (age, sex, and race) [3].
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fig1: Performance of estimating equations by age, gender, BMI, and diabetes status. Referent equation: serum creatinine 2009 equation (age, sex, and race) [3].

Mentions: Compared to creatinine 2009 equation, the median difference in eGFR was larger when using the “cystatin C 2012 equation” than the “creatinine in combination with cystatin C 2012 equation” (Figure 1). The differences were the greatest in the elderly (age >65 years), women, obese (BMI >30), and nondiabetic participants.


Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians.

Teo BW, Sabanayagam C, Liao J, Toh QC, Saw S, Wong TY, Sethi S - Int J Nephrol (2014)

Performance of estimating equations by age, gender, BMI, and diabetes status. Referent equation: serum creatinine 2009 equation (age, sex, and race) [3].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020461&req=5

fig1: Performance of estimating equations by age, gender, BMI, and diabetes status. Referent equation: serum creatinine 2009 equation (age, sex, and race) [3].
Mentions: Compared to creatinine 2009 equation, the median difference in eGFR was larger when using the “cystatin C 2012 equation” than the “creatinine in combination with cystatin C 2012 equation” (Figure 1). The differences were the greatest in the elderly (age >65 years), women, obese (BMI >30), and nondiabetic participants.

Bottom Line: Results.Conclusions.Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, Singapore 119228.

ABSTRACT
Background. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may improve eGFR accuracy. We evaluated the new CKD-EPI equations incorporating cystatin C in a population of Asian Indians in classifying CKD across body mass index, diabetes, and hypertension status. Methods. We retrieved standardized serum creatinine and serum cystatin C data from a cohort of 2877 Asian Indians aged 40-80 years from the Singapore Indian Eye Study and calculated eGFR (in mL/min/1.73 m(2)) with the new CKD-EPI equations and serum creatinine only equation. Results. The creatinine only equation mean eGFR (88 ± 17) was similar to using spline Log cystatin C (88 ± 22). The lowest mean eGFR (81 ± 21) was obtained with the spline Log cystatin C-age, sex, and weight equation. The creatinine only equation had the fewest participants (7.1%) with eGFR <60 and spline Log cystatin C-age, sex, and weight equation had the most (16.1%). Conclusions. Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.

No MeSH data available.


Related in: MedlinePlus