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Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis.

Guo H, Zhu SF, Zhang RR, Zhao XL, Wan MH, Tang WF - Evid Based Complement Alternat Med (2014)

Bottom Line: EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05).EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.

ABSTRACT
Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and large intestine are interior exteriorly related" in traditional Chinese medicine. Methods. Male Sprague-Dawley rats were randomly divided into the normal group, model group, and EA group. AP model was established by three injections of 20% L-arginine at 1 h intervals. EA were applied to bilateral ST-25 and ST-36 for 30 minutes twice a day after modeling for 3 days. Arterial blood, pancreas, lung, and intestinal tissues were collected for detecting the inflammatory factors and histopathology. Intestinal propulsion rate (IPR) was also measured at 72 h. Results. EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05). It lowered the serum levels of TNF- α and IL-6 and increased the level of IL-4 with no effect on IL-10. EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05). Conclusion. EA treatment could promote gastrointestinal motility through inhibiting VIP, and promoting CCK expression and regulate pro- and anti-inflammatory mediators to ameliorate ALI in AP.

No MeSH data available.


Related in: MedlinePlus

MPO in lung (a), pathological changes of pancreas, lung, and small intestine (b).
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fig4: MPO in lung (a), pathological changes of pancreas, lung, and small intestine (b).

Mentions: As shown in Figure 4(a), MPO activities in the lung of AP model group were markedly higher than those in the normal group. The level of MPO in EA group was significantly lower than that in the model group after 2-day treatment in rats with AP. This showed that EA treatment could ameliorate ALI induced by AP, which is further identified by the pathological assessment.


Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis.

Guo H, Zhu SF, Zhang RR, Zhao XL, Wan MH, Tang WF - Evid Based Complement Alternat Med (2014)

MPO in lung (a), pathological changes of pancreas, lung, and small intestine (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020394&req=5

fig4: MPO in lung (a), pathological changes of pancreas, lung, and small intestine (b).
Mentions: As shown in Figure 4(a), MPO activities in the lung of AP model group were markedly higher than those in the normal group. The level of MPO in EA group was significantly lower than that in the model group after 2-day treatment in rats with AP. This showed that EA treatment could ameliorate ALI induced by AP, which is further identified by the pathological assessment.

Bottom Line: EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05).EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05).Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.

ABSTRACT
Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and large intestine are interior exteriorly related" in traditional Chinese medicine. Methods. Male Sprague-Dawley rats were randomly divided into the normal group, model group, and EA group. AP model was established by three injections of 20% L-arginine at 1 h intervals. EA were applied to bilateral ST-25 and ST-36 for 30 minutes twice a day after modeling for 3 days. Arterial blood, pancreas, lung, and intestinal tissues were collected for detecting the inflammatory factors and histopathology. Intestinal propulsion rate (IPR) was also measured at 72 h. Results. EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05). It lowered the serum levels of TNF- α and IL-6 and increased the level of IL-4 with no effect on IL-10. EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05). Conclusion. EA treatment could promote gastrointestinal motility through inhibiting VIP, and promoting CCK expression and regulate pro- and anti-inflammatory mediators to ameliorate ALI in AP.

No MeSH data available.


Related in: MedlinePlus