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Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery.

Phromsopha T, Baimark Y - Int J Biomater (2014)

Bottom Line: The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio.The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased.The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

View Article: PubMed Central - PubMed

Affiliation: Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, Thailand.

ABSTRACT
Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

No MeSH data available.


In vitro drug release profiles of drug-loaded blend microparticles prepared with starch/gelatin blend ratios of (⋄) 0/100, (Δ) 20/80, (□) 35/65, and (○) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin.
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fig6: In vitro drug release profiles of drug-loaded blend microparticles prepared with starch/gelatin blend ratios of (⋄) 0/100, (Δ) 20/80, (□) 35/65, and (○) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin.

Mentions: The methylene blue release from the gelatin microparticles crosslinked with 12.5 g and 25 g glutaraldehyde/100 g gelatin at 24 h release time was about 78% and 74%, respectively. The glutaraldehyde-crosslinking can decrease the methylene blue release content. This may be explained by the crosslinked structure of the gelatin matrix inhibiting the drug release. For all the crosslinked starch/gelatin blend microparticles, a sustained drug release can be obtained as shown in Figure 6. For starch/gelatin blend ratios of 0/100, 20/80, 35/65, and 50/50 (w/w), the drug release levels at 24 h were 78%, 85%, 93%, and 97%, respectively. The level of drug release steadily increased as the starch blend ratio increased.


Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery.

Phromsopha T, Baimark Y - Int J Biomater (2014)

In vitro drug release profiles of drug-loaded blend microparticles prepared with starch/gelatin blend ratios of (⋄) 0/100, (Δ) 20/80, (□) 35/65, and (○) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020388&req=5

fig6: In vitro drug release profiles of drug-loaded blend microparticles prepared with starch/gelatin blend ratios of (⋄) 0/100, (Δ) 20/80, (□) 35/65, and (○) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin.
Mentions: The methylene blue release from the gelatin microparticles crosslinked with 12.5 g and 25 g glutaraldehyde/100 g gelatin at 24 h release time was about 78% and 74%, respectively. The glutaraldehyde-crosslinking can decrease the methylene blue release content. This may be explained by the crosslinked structure of the gelatin matrix inhibiting the drug release. For all the crosslinked starch/gelatin blend microparticles, a sustained drug release can be obtained as shown in Figure 6. For starch/gelatin blend ratios of 0/100, 20/80, 35/65, and 50/50 (w/w), the drug release levels at 24 h were 78%, 85%, 93%, and 97%, respectively. The level of drug release steadily increased as the starch blend ratio increased.

Bottom Line: The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio.The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased.The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

View Article: PubMed Central - PubMed

Affiliation: Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, Thailand.

ABSTRACT
Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

No MeSH data available.