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Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery.

Phromsopha T, Baimark Y - Int J Biomater (2014)

Bottom Line: The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio.The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased.The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

View Article: PubMed Central - PubMed

Affiliation: Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, Thailand.

ABSTRACT
Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

No MeSH data available.


SEM images of drug-loaded gelatin microparticles (a) without crosslinking and crosslinked with (b) 12.5 g glutaraldehyde/100 g gelatin and (c) 25 g glutaraldehyde/100 g gelatin, and drug-loaded blend microparticles with starch/gelatin blend ratios of (d) 20/80, (e) 35/65, and (f) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin. (All bars = 100 μm.)
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fig1: SEM images of drug-loaded gelatin microparticles (a) without crosslinking and crosslinked with (b) 12.5 g glutaraldehyde/100 g gelatin and (c) 25 g glutaraldehyde/100 g gelatin, and drug-loaded blend microparticles with starch/gelatin blend ratios of (d) 20/80, (e) 35/65, and (f) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin. (All bars = 100 μm.)

Mentions: The morphology of the gelatin and blend microparticles with and without crosslinking was determined from SEM images as shown in Figure 1. All gelatin microparticles had deflated shapes and smooth surfaces with fine dispersibility (Figures 1(a)–1(c)). This may be due to them containing an internal porous structure. However, the gelatin microparticles crosslinked with 25 g glutaraldehyde/100 g gelatin, in Figure 1(c), were nearly spherical in shape.


Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery.

Phromsopha T, Baimark Y - Int J Biomater (2014)

SEM images of drug-loaded gelatin microparticles (a) without crosslinking and crosslinked with (b) 12.5 g glutaraldehyde/100 g gelatin and (c) 25 g glutaraldehyde/100 g gelatin, and drug-loaded blend microparticles with starch/gelatin blend ratios of (d) 20/80, (e) 35/65, and (f) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin. (All bars = 100 μm.)
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020388&req=5

fig1: SEM images of drug-loaded gelatin microparticles (a) without crosslinking and crosslinked with (b) 12.5 g glutaraldehyde/100 g gelatin and (c) 25 g glutaraldehyde/100 g gelatin, and drug-loaded blend microparticles with starch/gelatin blend ratios of (d) 20/80, (e) 35/65, and (f) 50/50 (w/w) crosslinked with 25 g glutaraldehyde/100 g starch/gelatin. (All bars = 100 μm.)
Mentions: The morphology of the gelatin and blend microparticles with and without crosslinking was determined from SEM images as shown in Figure 1. All gelatin microparticles had deflated shapes and smooth surfaces with fine dispersibility (Figures 1(a)–1(c)). This may be due to them containing an internal porous structure. However, the gelatin microparticles crosslinked with 25 g glutaraldehyde/100 g gelatin, in Figure 1(c), were nearly spherical in shape.

Bottom Line: The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio.The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased.The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

View Article: PubMed Central - PubMed

Affiliation: Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, Thailand.

ABSTRACT
Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.

No MeSH data available.