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Burkitt lymphoma of thyroid gland in an adolescent.

Cooper K, Gangadharan A, Arora RS, Shukla R, Pizer B - Case Rep Pediatr (2014)

Bottom Line: Burkitt Lymphoma is a highly aggressive form of non-Hodgkin's lymphoma that in nonendemic areas has abdominal primary sites.We report a very rare case of Burkitt lymphoma of the thyroid gland presenting as a rapidly growing thyroid swelling in a 14-year-old white Caucasian British male with no preexisting thyroid or medical problems.The patient was treated according to the Children's Cancer and Leukaemia Group guidelines for BL-Group B protocol and currently is in remission.

View Article: PubMed Central - PubMed

Affiliation: Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK.

ABSTRACT
Burkitt Lymphoma is a highly aggressive form of non-Hodgkin's lymphoma that in nonendemic areas has abdominal primary sites. We report a very rare case of Burkitt lymphoma of the thyroid gland presenting as a rapidly growing thyroid swelling in a 14-year-old white Caucasian British male with no preexisting thyroid or medical problems. The diagnosis was confirmed by an open wedge biopsy following a fine needle aspiration. The patient was treated according to the Children's Cancer and Leukaemia Group guidelines for BL-Group B protocol and currently is in remission.

No MeSH data available.


Related in: MedlinePlus

Histology from open wedge biopsy. The tumour showed diffuse sheets of lymphoid cells punctuated by tingible body macrophages (H&E 10X).
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fig1: Histology from open wedge biopsy. The tumour showed diffuse sheets of lymphoid cells punctuated by tingible body macrophages (H&E 10X).

Mentions: A fine needle aspiration biopsy was carried out and was suspicious of NHL. The diagnosis of Burkitt type NHL (BL) was made following an open wedge biopsy. On microscopic examination, the tumour was composed of diffuse sheets of lymphoid cells (Figure 1) having round nuclei with coarse chromatin and conspicuous single to multiple nucleoli and scanty amphophilic cytoplasm. Numerous mitotic figures, apoptosis, and scattered tingible body type macrophages were also present. Tumour cells were positive for CD79A, CD20, and CD10 and negative for TdT and T cell markers (CD3, CD4, and CD8). Ki 67 showed proliferation index approaching 100%. Immunohistochemistry for EBV was negative. The diagnosis of BL was confirmed on fluorescence in situ hybridisation that showed tumour cell positivity for the t(8; 14) translocation.


Burkitt lymphoma of thyroid gland in an adolescent.

Cooper K, Gangadharan A, Arora RS, Shukla R, Pizer B - Case Rep Pediatr (2014)

Histology from open wedge biopsy. The tumour showed diffuse sheets of lymphoid cells punctuated by tingible body macrophages (H&E 10X).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020368&req=5

fig1: Histology from open wedge biopsy. The tumour showed diffuse sheets of lymphoid cells punctuated by tingible body macrophages (H&E 10X).
Mentions: A fine needle aspiration biopsy was carried out and was suspicious of NHL. The diagnosis of Burkitt type NHL (BL) was made following an open wedge biopsy. On microscopic examination, the tumour was composed of diffuse sheets of lymphoid cells (Figure 1) having round nuclei with coarse chromatin and conspicuous single to multiple nucleoli and scanty amphophilic cytoplasm. Numerous mitotic figures, apoptosis, and scattered tingible body type macrophages were also present. Tumour cells were positive for CD79A, CD20, and CD10 and negative for TdT and T cell markers (CD3, CD4, and CD8). Ki 67 showed proliferation index approaching 100%. Immunohistochemistry for EBV was negative. The diagnosis of BL was confirmed on fluorescence in situ hybridisation that showed tumour cell positivity for the t(8; 14) translocation.

Bottom Line: Burkitt Lymphoma is a highly aggressive form of non-Hodgkin's lymphoma that in nonendemic areas has abdominal primary sites.We report a very rare case of Burkitt lymphoma of the thyroid gland presenting as a rapidly growing thyroid swelling in a 14-year-old white Caucasian British male with no preexisting thyroid or medical problems.The patient was treated according to the Children's Cancer and Leukaemia Group guidelines for BL-Group B protocol and currently is in remission.

View Article: PubMed Central - PubMed

Affiliation: Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK.

ABSTRACT
Burkitt Lymphoma is a highly aggressive form of non-Hodgkin's lymphoma that in nonendemic areas has abdominal primary sites. We report a very rare case of Burkitt lymphoma of the thyroid gland presenting as a rapidly growing thyroid swelling in a 14-year-old white Caucasian British male with no preexisting thyroid or medical problems. The diagnosis was confirmed by an open wedge biopsy following a fine needle aspiration. The patient was treated according to the Children's Cancer and Leukaemia Group guidelines for BL-Group B protocol and currently is in remission.

No MeSH data available.


Related in: MedlinePlus