Limits...
Carbon nanotubes: an emerging drug carrier for targeting cancer cells.

Rastogi V, Yadav P, Bhattacharya SS, Mishra AK, Verma N, Verma A, Pandit JK - J Drug Deliv (2014)

Bottom Line: To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions.This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent.Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244001, India.

ABSTRACT
During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

No MeSH data available.


Related in: MedlinePlus

Schematic illustration of functionalization of CNTs with various molecules: (a) Prakash et al. [18], (b) Xiao et al. [78], (c) Xu et al. [70], (d) Gomez-Gualdron et al. [64], (e) Bianco et al. [79], (f) Jiang et al. [80], (g) Williams et al. [81], and (h) Kam and Dai [82].
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4020363&req=5

fig4: Schematic illustration of functionalization of CNTs with various molecules: (a) Prakash et al. [18], (b) Xiao et al. [78], (c) Xu et al. [70], (d) Gomez-Gualdron et al. [64], (e) Bianco et al. [79], (f) Jiang et al. [80], (g) Williams et al. [81], and (h) Kam and Dai [82].

Mentions: Schematic representation of functionalized CNTs with various molecules is given in Figure 4. The functionalization can be divided into two main subcategories: noncovalent functionalization and covalent functionalization.


Carbon nanotubes: an emerging drug carrier for targeting cancer cells.

Rastogi V, Yadav P, Bhattacharya SS, Mishra AK, Verma N, Verma A, Pandit JK - J Drug Deliv (2014)

Schematic illustration of functionalization of CNTs with various molecules: (a) Prakash et al. [18], (b) Xiao et al. [78], (c) Xu et al. [70], (d) Gomez-Gualdron et al. [64], (e) Bianco et al. [79], (f) Jiang et al. [80], (g) Williams et al. [81], and (h) Kam and Dai [82].
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020363&req=5

fig4: Schematic illustration of functionalization of CNTs with various molecules: (a) Prakash et al. [18], (b) Xiao et al. [78], (c) Xu et al. [70], (d) Gomez-Gualdron et al. [64], (e) Bianco et al. [79], (f) Jiang et al. [80], (g) Williams et al. [81], and (h) Kam and Dai [82].
Mentions: Schematic representation of functionalized CNTs with various molecules is given in Figure 4. The functionalization can be divided into two main subcategories: noncovalent functionalization and covalent functionalization.

Bottom Line: To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions.This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent.Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244001, India.

ABSTRACT
During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

No MeSH data available.


Related in: MedlinePlus