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Carbon nanotubes: an emerging drug carrier for targeting cancer cells.

Rastogi V, Yadav P, Bhattacharya SS, Mishra AK, Verma N, Verma A, Pandit JK - J Drug Deliv (2014)

Bottom Line: CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes.To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions.Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244001, India.

ABSTRACT
During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

No MeSH data available.


Related in: MedlinePlus

Mechanism of carbon nanotube synthesis: (a) Arc discharge method, (b) chemical vapor deposition method, and (c) laser ablation method.
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Related In: Results  -  Collection


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fig3: Mechanism of carbon nanotube synthesis: (a) Arc discharge method, (b) chemical vapor deposition method, and (c) laser ablation method.

Mentions: Presently, there are three main approaches for the synthesis of CNTs (Figures 2 and 3) including electric arc discharge, the laser ablation and the chemical vapor deposition (CVD).


Carbon nanotubes: an emerging drug carrier for targeting cancer cells.

Rastogi V, Yadav P, Bhattacharya SS, Mishra AK, Verma N, Verma A, Pandit JK - J Drug Deliv (2014)

Mechanism of carbon nanotube synthesis: (a) Arc discharge method, (b) chemical vapor deposition method, and (c) laser ablation method.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020363&req=5

fig3: Mechanism of carbon nanotube synthesis: (a) Arc discharge method, (b) chemical vapor deposition method, and (c) laser ablation method.
Mentions: Presently, there are three main approaches for the synthesis of CNTs (Figures 2 and 3) including electric arc discharge, the laser ablation and the chemical vapor deposition (CVD).

Bottom Line: CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes.To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions.Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244001, India.

ABSTRACT
During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

No MeSH data available.


Related in: MedlinePlus