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Abnormal baseline brain activity in patients with pulsatile tinnitus: a resting-state FMRI study.

Han L, Zhaohui L, Fei Y, Ting L, Pengfei Z, Wang D, Cheng D, Pengde G, Xiaoyi H, Xiao W, Rui L, Zhenchang W - Neural Plast. (2014)

Bottom Line: Compared with normal controls, PT patients did not show any structural changes.PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas.The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

ABSTRACT
Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n = 42) and age-, sex-, and education-matched normal control subjects (n = 42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

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Related in: MedlinePlus

Altered ALFF in PT patients in comparison with controls (two-sample t-tests).
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Related In: Results  -  Collection


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fig1: Altered ALFF in PT patients in comparison with controls (two-sample t-tests).

Mentions: Two-sample t-tests were performed to assess differences between groups. As shown in Figure 1 and Table 2, after statistically controlling for the age, the bilateral precuneus and inferior frontal gyrus (IFG) showed significantly increased ALFF in the pulsatile tinnitus patients than that in the controls. However, compared to the controls, the left cuneus, right precentral gyrus, and the bilateral middle-inferior occipital gyrus, lingual gyrus, and right superior parietal lobule significantly decreased ALFF in the pulsatile tinnitus patients.


Abnormal baseline brain activity in patients with pulsatile tinnitus: a resting-state FMRI study.

Han L, Zhaohui L, Fei Y, Ting L, Pengfei Z, Wang D, Cheng D, Pengde G, Xiaoyi H, Xiao W, Rui L, Zhenchang W - Neural Plast. (2014)

Altered ALFF in PT patients in comparison with controls (two-sample t-tests).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020302&req=5

fig1: Altered ALFF in PT patients in comparison with controls (two-sample t-tests).
Mentions: Two-sample t-tests were performed to assess differences between groups. As shown in Figure 1 and Table 2, after statistically controlling for the age, the bilateral precuneus and inferior frontal gyrus (IFG) showed significantly increased ALFF in the pulsatile tinnitus patients than that in the controls. However, compared to the controls, the left cuneus, right precentral gyrus, and the bilateral middle-inferior occipital gyrus, lingual gyrus, and right superior parietal lobule significantly decreased ALFF in the pulsatile tinnitus patients.

Bottom Line: Compared with normal controls, PT patients did not show any structural changes.PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas.The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

ABSTRACT
Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n = 42) and age-, sex-, and education-matched normal control subjects (n = 42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

Show MeSH
Related in: MedlinePlus