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Effect of pregabalin and dexamethasone on postoperative analgesia after septoplasty.

Demirhan A, Akkaya A, Tekelioglu UY, Apuhan T, Bilgi M, Yurttas V, Bayir H, Yildiz I, Gok U, Kocoglu H - Pain Res Treat (2014)

Bottom Line: The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (P < 0.001 and P < 0.001).Conclusions.Addition of dexamethasone does not significantly reduce pain in these patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.

ABSTRACT
Objectives. The aim of this study was to explore effect of a combination of pregabalin and dexamethasone on pain control after septoplasty operations. Methods. In this study, 90 patients who were scheduled for septoplasty under general anesthesia were randomly assigned into groups that received either placebo (Group C), pregabalin (Group P), or pregabalin and dexamethasone (Group PD). Preoperatively, patients received either pregabalin 300 mg one hour before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain treatment included tramadol and diclofenac sodium 30 minutes before the end of the operation. Numeric rating scale (NRS) for pain assessment, side effects, and consumption of tramadol, pethidine, and ondansetron were recorded. Results. The median NRS score at the postoperative 0 and the 2nd h was significantly higher in Group C than in Group P and Group PD (P ≤ 0.004 for both). The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (P < 0.001 and P < 0.001). The incidence of blurred vision was significantly higher in Group PD compared to Group C within both 0-2 h and 0-24 h periods (P = 0.002 and P < 0.001, resp.). Conclusions. We conclude that administration of 300 mg pregabalin preoperatively may be an adequate choice for pain control after septoplasty. Addition of dexamethasone does not significantly reduce pain in these patients.

No MeSH data available.


Related in: MedlinePlus

Consumption of tramadol.
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fig1: Consumption of tramadol.

Mentions: Group P and Group PD showed statistically significant lower tramadol consumption compared to Group C within the postoperative 0–24 h period (P < 0.001 for all). There was no statistically significant difference between the Group P and Group PD in terms of tramadol consumption (P > 0.05 for all). Table 2 shows the mean tramadol consumption (mg) of the groups within the first 24 h period (Figure 1).


Effect of pregabalin and dexamethasone on postoperative analgesia after septoplasty.

Demirhan A, Akkaya A, Tekelioglu UY, Apuhan T, Bilgi M, Yurttas V, Bayir H, Yildiz I, Gok U, Kocoglu H - Pain Res Treat (2014)

Consumption of tramadol.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020296&req=5

fig1: Consumption of tramadol.
Mentions: Group P and Group PD showed statistically significant lower tramadol consumption compared to Group C within the postoperative 0–24 h period (P < 0.001 for all). There was no statistically significant difference between the Group P and Group PD in terms of tramadol consumption (P > 0.05 for all). Table 2 shows the mean tramadol consumption (mg) of the groups within the first 24 h period (Figure 1).

Bottom Line: The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (P < 0.001 and P < 0.001).Conclusions.Addition of dexamethasone does not significantly reduce pain in these patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey.

ABSTRACT
Objectives. The aim of this study was to explore effect of a combination of pregabalin and dexamethasone on pain control after septoplasty operations. Methods. In this study, 90 patients who were scheduled for septoplasty under general anesthesia were randomly assigned into groups that received either placebo (Group C), pregabalin (Group P), or pregabalin and dexamethasone (Group PD). Preoperatively, patients received either pregabalin 300 mg one hour before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain treatment included tramadol and diclofenac sodium 30 minutes before the end of the operation. Numeric rating scale (NRS) for pain assessment, side effects, and consumption of tramadol, pethidine, and ondansetron were recorded. Results. The median NRS score at the postoperative 0 and the 2nd h was significantly higher in Group C than in Group P and Group PD (P ≤ 0.004 for both). The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (P < 0.001 and P < 0.001). The incidence of blurred vision was significantly higher in Group PD compared to Group C within both 0-2 h and 0-24 h periods (P = 0.002 and P < 0.001, resp.). Conclusions. We conclude that administration of 300 mg pregabalin preoperatively may be an adequate choice for pain control after septoplasty. Addition of dexamethasone does not significantly reduce pain in these patients.

No MeSH data available.


Related in: MedlinePlus