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Effects of soybean product intake on fasting and postload hyperglycemia and type 2 diabetes in Japanese men with high body mass index: The Saku Study.

Tatsumi Y, Morimoto A, Deura K, Mizuno S, Ohno Y, Watanabe S - J Diabetes Investig (2013)

Bottom Line: Participants were stratified by sex and body mass index (BMI), and further classified into three groups based on soybean product intake: group 1 (0-1 time/week), group 2 (2-3 times/week) and group 3 (four or more times per week).Similar results were not observed among men with low BMI or women.Further long-term observation is necessary.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematical Health Science Graduate School of Medicine Osaka University Osaka Japan.

ABSTRACT

Aims/introduction: The inverse association between soybean intake and type 2 diabetes mellitus has been reported. We investigated the effects of soybean product intake on the incidence of type 2 diabetes mellitus considering fasting and postload hyperglycemia.

Materials and methods: The present 4-year, cohort study included 1,738 men and 1,301 women, aged 30-69 years, without diabetes mellitus at baseline who underwent comprehensive medical check-ups between April 2006 and March 2007 at Saku Central Hospital. Participants were stratified by sex and body mass index (BMI), and further classified into three groups based on soybean product intake: group 1 (0-1 time/week), group 2 (2-3 times/week) and group 3 (four or more times per week). Participants underwent annual standard 75-g oral glucose tolerance testing during follow-up periods until March 2011. Main outcomes were incidence of fasting hyperglycemia, postload hyperglycemia and type 2 diabetes mellitus.

Results: During 10,503 person-years of follow up, 204 participants developed type 2 diabetes mellitus, including 61 who developed fasting hyperglycemia and 147 who developed postload hyperglycemia. Among men with a high BMI, group 3 had significantly lower risk for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than group 1, and multivariable-adjusted hazard ratios and 95% confidence intervals were 0.44 (0.22-0.89), 0.36 (0.15-0.96) and 0.40 (0.18-0.92), respectively. Similar results were not observed among men with low BMI or women.

Conclusions: Soybean product intake prevented fasting and postload hyperglycemia and type 2 diabetes mellitus in men with a high BMI. Further long-term observation is necessary.

No MeSH data available.


Related in: MedlinePlus

Fasting plasma glucose (FPG) levels and 2‐h plasma glucose (PG) levels at the end of follow up among men. (a) Men with low body mass index (BMI). (b) Men with high BMI. The circles show group 1, the squares show group 2 and the triangles show group 3.
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jdi12100-fig-0001: Fasting plasma glucose (FPG) levels and 2‐h plasma glucose (PG) levels at the end of follow up among men. (a) Men with low body mass index (BMI). (b) Men with high BMI. The circles show group 1, the squares show group 2 and the triangles show group 3.

Mentions: The median follow up was 4.0 years (total person‐years: 10,503), during which 204 individuals developed type 2 diabetes mellitus, including 26 defined as having type 2 diabetes mellitus by receiving medical treatment for this disease. Of those, 61 participants developed fasting hyperglycemia and 147 participants developed postload hyperglycemia. Because the youngest of these individuals was 40‐years‐old at baseline, all incident cases were assumed to be type 2 diabetes mellitus. Table 3 shows the multivariable‐adjusted HRs and 95% CIs for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia according to groups categorized by soybean product intake in men. Among men with a high BMI, men of group 3 had a significantly lower risk for incidences of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than men of group 1, and the multivariable‐adjusted HRs and 95% CIs were 0.44 (0.22–0.89), 0.36 (0.15–0.96) and 0.40 (0.18–0.92), respectively. In addition, there were significant linear decreases in the multivariable‐adjusted HRs for the incidence of type 2 diabetes mellitus and postload hyperglycemia (P for trend = 0.014 and 0.032, respectively). Figure 1 shows FPG and 2‐h PG levels at the follow‐up end among men who were diagnosed type 2 diabetes mellitus by 75‐g OGTT. Of the men who developed type 2 diabetes mellitus among the men with high BMI, the number of men whose HbA1c increased to more than 6.5% was eight (group 1: 0, group 2: 4, group 3: 4). When high BMI was defined as BMI ≥25.0 kg/m2, the number of men with high BMI were 514 (group 1: 37, group 2: 189, group 3: 288) and the multivariable‐adjusted HRs and 95% CIs for type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia among group 3 in men with high BMI were 0.35 (0.15–0.81), 0.32 (0.09–1.11) and 0.31 (0.12–0.83), respectively. These significant associations between soybean product intake and incidence of type 2 diabetes mellitus were observed after further adjustment for fish intakes.


Effects of soybean product intake on fasting and postload hyperglycemia and type 2 diabetes in Japanese men with high body mass index: The Saku Study.

Tatsumi Y, Morimoto A, Deura K, Mizuno S, Ohno Y, Watanabe S - J Diabetes Investig (2013)

Fasting plasma glucose (FPG) levels and 2‐h plasma glucose (PG) levels at the end of follow up among men. (a) Men with low body mass index (BMI). (b) Men with high BMI. The circles show group 1, the squares show group 2 and the triangles show group 3.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020259&req=5

jdi12100-fig-0001: Fasting plasma glucose (FPG) levels and 2‐h plasma glucose (PG) levels at the end of follow up among men. (a) Men with low body mass index (BMI). (b) Men with high BMI. The circles show group 1, the squares show group 2 and the triangles show group 3.
Mentions: The median follow up was 4.0 years (total person‐years: 10,503), during which 204 individuals developed type 2 diabetes mellitus, including 26 defined as having type 2 diabetes mellitus by receiving medical treatment for this disease. Of those, 61 participants developed fasting hyperglycemia and 147 participants developed postload hyperglycemia. Because the youngest of these individuals was 40‐years‐old at baseline, all incident cases were assumed to be type 2 diabetes mellitus. Table 3 shows the multivariable‐adjusted HRs and 95% CIs for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia according to groups categorized by soybean product intake in men. Among men with a high BMI, men of group 3 had a significantly lower risk for incidences of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than men of group 1, and the multivariable‐adjusted HRs and 95% CIs were 0.44 (0.22–0.89), 0.36 (0.15–0.96) and 0.40 (0.18–0.92), respectively. In addition, there were significant linear decreases in the multivariable‐adjusted HRs for the incidence of type 2 diabetes mellitus and postload hyperglycemia (P for trend = 0.014 and 0.032, respectively). Figure 1 shows FPG and 2‐h PG levels at the follow‐up end among men who were diagnosed type 2 diabetes mellitus by 75‐g OGTT. Of the men who developed type 2 diabetes mellitus among the men with high BMI, the number of men whose HbA1c increased to more than 6.5% was eight (group 1: 0, group 2: 4, group 3: 4). When high BMI was defined as BMI ≥25.0 kg/m2, the number of men with high BMI were 514 (group 1: 37, group 2: 189, group 3: 288) and the multivariable‐adjusted HRs and 95% CIs for type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia among group 3 in men with high BMI were 0.35 (0.15–0.81), 0.32 (0.09–1.11) and 0.31 (0.12–0.83), respectively. These significant associations between soybean product intake and incidence of type 2 diabetes mellitus were observed after further adjustment for fish intakes.

Bottom Line: Participants were stratified by sex and body mass index (BMI), and further classified into three groups based on soybean product intake: group 1 (0-1 time/week), group 2 (2-3 times/week) and group 3 (four or more times per week).Similar results were not observed among men with low BMI or women.Further long-term observation is necessary.

View Article: PubMed Central - PubMed

Affiliation: Department of Mathematical Health Science Graduate School of Medicine Osaka University Osaka Japan.

ABSTRACT

Aims/introduction: The inverse association between soybean intake and type 2 diabetes mellitus has been reported. We investigated the effects of soybean product intake on the incidence of type 2 diabetes mellitus considering fasting and postload hyperglycemia.

Materials and methods: The present 4-year, cohort study included 1,738 men and 1,301 women, aged 30-69 years, without diabetes mellitus at baseline who underwent comprehensive medical check-ups between April 2006 and March 2007 at Saku Central Hospital. Participants were stratified by sex and body mass index (BMI), and further classified into three groups based on soybean product intake: group 1 (0-1 time/week), group 2 (2-3 times/week) and group 3 (four or more times per week). Participants underwent annual standard 75-g oral glucose tolerance testing during follow-up periods until March 2011. Main outcomes were incidence of fasting hyperglycemia, postload hyperglycemia and type 2 diabetes mellitus.

Results: During 10,503 person-years of follow up, 204 participants developed type 2 diabetes mellitus, including 61 who developed fasting hyperglycemia and 147 who developed postload hyperglycemia. Among men with a high BMI, group 3 had significantly lower risk for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than group 1, and multivariable-adjusted hazard ratios and 95% confidence intervals were 0.44 (0.22-0.89), 0.36 (0.15-0.96) and 0.40 (0.18-0.92), respectively. Similar results were not observed among men with low BMI or women.

Conclusions: Soybean product intake prevented fasting and postload hyperglycemia and type 2 diabetes mellitus in men with a high BMI. Further long-term observation is necessary.

No MeSH data available.


Related in: MedlinePlus