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Usefulness of a novel system for measuring glucose area under the curve while screening for glucose intolerance in outpatients.

Sakamoto K, Kubo F, Yoshiuchi K, Ono A, Sato T, Tomita K, Sakaguchi K, Matsuhisa M, Kaneto H, Maegawa H, Nakajima H, Kashiwagi A, Kosugi K - J Diabetes Investig (2013)

Bottom Line: Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference (actual) AUC.Good correlation between MIET-predicted and reference AUCs obtained using PG levels was confirmed for a wide AUC range.The results of a questionnaire-based survey administered to the subjects suggested that this system was readily accepted by the majority as a painless monitoring method.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine Osaka Police Hospital Osaka Japan.

ABSTRACT

Aims/introduction: To realize the effectiveness of a novel system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET), outpatients undergoing oral glucose tolerance tests (OGTT) were investigated for the efficacy of screening for glucose intolerance using this system.

Materials and methods: Fifty outpatients scheduled to undergo a 75-g OGTT for medical reasons were recruited to the study. An area of skin on the forearm was pretreated with microneedle arrays before the application of hydrogels for interstitial fluid extraction. Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference (actual) AUC. The AUC was predicted by MIET on the basis of glucose extracted by the hydrogel using sodium ion levels as the internal standard.

Results: Good correlation between MIET-predicted and reference AUCs obtained using PG levels was confirmed for a wide AUC range. By introducing a threshold level for AUC to separate glucose intolerance with peak glucose ≥180 mg/dL from normal glucose tolerance, the system was demonstrated to provide better screening accuracy compared with conventional methods that use HbA1c and fasting PG levels. The results of a questionnaire-based survey administered to the subjects suggested that this system was readily accepted by the majority as a painless monitoring method.

Conclusions: The findings suggest that our glucose AUC measurement system using MIET would be useful for screening of glucose intolerance. In the future, this system may prove to be a useful aid as a screen for glucose intolerance before performing an OGTT for diagnosis.

No MeSH data available.


Related in: MedlinePlus

Plasma glucose profiles indicative of (a) normal glucose tolerance, (b) impaired fasting glucose, (c) impaired glucose tolerance, and (d) diabetes mellitus after the oral glucose tolerance test. Open symbols, peak plasma glucose <180 mg/dL; filled symbols, peak plasma glucose ≥180 mg/dL.
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jdi12096-fig-0001: Plasma glucose profiles indicative of (a) normal glucose tolerance, (b) impaired fasting glucose, (c) impaired glucose tolerance, and (d) diabetes mellitus after the oral glucose tolerance test. Open symbols, peak plasma glucose <180 mg/dL; filled symbols, peak plasma glucose ≥180 mg/dL.

Mentions: Figure 1 shows the PG profiles classified according to the diagnostic criteria. Of the 15 profiles for NGT, four showed peak glucose ≥180 mg/dL. There were two and four profiles for IFG and IGT, respectively, with peak glucose <180 mg/dL. As shown in Figure 1, times for peak PG were class dependent and occurred mainly at 30–60 min in cases of NGT and IFG, at 60 min in cases of IGT, and at 60–120 min in cases of diabetes. Furthermore, IGT profiles showed wide variability at 30–90 min, in contrast with the variation in diabetes profiles that were observed at 120 min.


Usefulness of a novel system for measuring glucose area under the curve while screening for glucose intolerance in outpatients.

Sakamoto K, Kubo F, Yoshiuchi K, Ono A, Sato T, Tomita K, Sakaguchi K, Matsuhisa M, Kaneto H, Maegawa H, Nakajima H, Kashiwagi A, Kosugi K - J Diabetes Investig (2013)

Plasma glucose profiles indicative of (a) normal glucose tolerance, (b) impaired fasting glucose, (c) impaired glucose tolerance, and (d) diabetes mellitus after the oral glucose tolerance test. Open symbols, peak plasma glucose <180 mg/dL; filled symbols, peak plasma glucose ≥180 mg/dL.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020250&req=5

jdi12096-fig-0001: Plasma glucose profiles indicative of (a) normal glucose tolerance, (b) impaired fasting glucose, (c) impaired glucose tolerance, and (d) diabetes mellitus after the oral glucose tolerance test. Open symbols, peak plasma glucose <180 mg/dL; filled symbols, peak plasma glucose ≥180 mg/dL.
Mentions: Figure 1 shows the PG profiles classified according to the diagnostic criteria. Of the 15 profiles for NGT, four showed peak glucose ≥180 mg/dL. There were two and four profiles for IFG and IGT, respectively, with peak glucose <180 mg/dL. As shown in Figure 1, times for peak PG were class dependent and occurred mainly at 30–60 min in cases of NGT and IFG, at 60 min in cases of IGT, and at 60–120 min in cases of diabetes. Furthermore, IGT profiles showed wide variability at 30–90 min, in contrast with the variation in diabetes profiles that were observed at 120 min.

Bottom Line: Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference (actual) AUC.Good correlation between MIET-predicted and reference AUCs obtained using PG levels was confirmed for a wide AUC range.The results of a questionnaire-based survey administered to the subjects suggested that this system was readily accepted by the majority as a painless monitoring method.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine Osaka Police Hospital Osaka Japan.

ABSTRACT

Aims/introduction: To realize the effectiveness of a novel system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET), outpatients undergoing oral glucose tolerance tests (OGTT) were investigated for the efficacy of screening for glucose intolerance using this system.

Materials and methods: Fifty outpatients scheduled to undergo a 75-g OGTT for medical reasons were recruited to the study. An area of skin on the forearm was pretreated with microneedle arrays before the application of hydrogels for interstitial fluid extraction. Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference (actual) AUC. The AUC was predicted by MIET on the basis of glucose extracted by the hydrogel using sodium ion levels as the internal standard.

Results: Good correlation between MIET-predicted and reference AUCs obtained using PG levels was confirmed for a wide AUC range. By introducing a threshold level for AUC to separate glucose intolerance with peak glucose ≥180 mg/dL from normal glucose tolerance, the system was demonstrated to provide better screening accuracy compared with conventional methods that use HbA1c and fasting PG levels. The results of a questionnaire-based survey administered to the subjects suggested that this system was readily accepted by the majority as a painless monitoring method.

Conclusions: The findings suggest that our glucose AUC measurement system using MIET would be useful for screening of glucose intolerance. In the future, this system may prove to be a useful aid as a screen for glucose intolerance before performing an OGTT for diagnosis.

No MeSH data available.


Related in: MedlinePlus