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Prevalence of retinopathy and its risk factors in a Japanese population.

Fukushima S, Nakagami T, Suto C, Hirose A, Uchigata Y - J Diabetes Investig (2013)

Bottom Line: The study comprises 1,864 Japanese who participated in the general health check-up program and did not have a previous history of cardiovascular disease.Non-mydriatic 45° digital fundus photographs were taken twice annually.However, a statistically significant increased risk of retinopathy remained only in participants with FPG ≥ 7.0 mmol/L or HbA1c ≥ 6.5% compared with those with the lowest quartile of glucose in the participants without previously diagnosed diabetes after adjusting for age and SBP.

View Article: PubMed Central - PubMed

Affiliation: Diabetes Center Tokyo Women's Medical University School of Medicine Tokyo Japan.

ABSTRACT

Aims/introduction: To determine the prevalence and risk factors of retinopathy and validity of the current diagnostic cut-offs for diabetes by using data of health check-up examinees.

Materials and methods: The study comprises 1,864 Japanese who participated in the general health check-up program and did not have a previous history of cardiovascular disease. Non-mydriatic 45° digital fundus photographs were taken twice annually. Multivariate logistic regression model was used to identify risk factors for retinopathy in participants without previously diagnosed diabetes.

Results: The overall prevalence of retinopathy in participants with and without previously diagnosed diabetes were 23.3% (28/120) and 4.2% (74/1,744), respectively. Univariate logistic regression analysis identified age, systolic blood pressure (SBP), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) as risk factors for retinopathy. Multivariate logistic regression analysis showed that FPG or both HbA1c and SBP were significant, positive and independent risk factors for retinopathy. The prevalence of retinopathy increased with deterioration of glucose categories (P < 0.001 for FPG or HbA1c). However, a statistically significant increased risk of retinopathy remained only in participants with FPG ≥ 7.0 mmol/L or HbA1c ≥ 6.5% compared with those with the lowest quartile of glucose in the participants without previously diagnosed diabetes after adjusting for age and SBP.

Conclusions: The prevalence of retinopathy was 4.2%, and FPG or both HbA1c and SBP were positive and independent risk factors for retinopathy in health check-up examinees without previously diagnosed diabetes. The FPG 7.0 mmol/L or HbA1c 6.5% seems to be appropriate to diagnose diabetes in view of its association with retinopathy.

No MeSH data available.


Related in: MedlinePlus

The prevalence of retinopathy based on six glucose categories for (a) fasting plasma glucose (FPG) and (b) hemoglobin A1c (HbA1c). *P < 0.05. DM, diabetes mellitus.
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jdi12044-fig-0001: The prevalence of retinopathy based on six glucose categories for (a) fasting plasma glucose (FPG) and (b) hemoglobin A1c (HbA1c). *P < 0.05. DM, diabetes mellitus.

Mentions: Figure 1 shows the relationship between the crude prevalence of retinopathy and the six glucose categories based on FPG or HbA1c. The prevalence of retinopathy increased with deterioration of glucose categories for each of HbA1c and FPG (P < 0.001 for FPG or HbA1c category) (Figure 1) and FPG or HbA1c category was significantly associated with retinopathy. When no adjustment was made, the statistically significant increase in the risk of retinopathy was observed in participants with the category of FPG ≥5.5 mmol/L or HbA1c ≥6.5% in comparison with participants in the category of the lowest FPG or HbA1c. However, this statistically significant increased risk of retinopathy remained only in participants with FPG ≥7.0 mmol/L or HbA1c ≥6.5% compared with participants with the lowest FPG or HbA1c after adjusting for age and SBP.


Prevalence of retinopathy and its risk factors in a Japanese population.

Fukushima S, Nakagami T, Suto C, Hirose A, Uchigata Y - J Diabetes Investig (2013)

The prevalence of retinopathy based on six glucose categories for (a) fasting plasma glucose (FPG) and (b) hemoglobin A1c (HbA1c). *P < 0.05. DM, diabetes mellitus.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4020228&req=5

jdi12044-fig-0001: The prevalence of retinopathy based on six glucose categories for (a) fasting plasma glucose (FPG) and (b) hemoglobin A1c (HbA1c). *P < 0.05. DM, diabetes mellitus.
Mentions: Figure 1 shows the relationship between the crude prevalence of retinopathy and the six glucose categories based on FPG or HbA1c. The prevalence of retinopathy increased with deterioration of glucose categories for each of HbA1c and FPG (P < 0.001 for FPG or HbA1c category) (Figure 1) and FPG or HbA1c category was significantly associated with retinopathy. When no adjustment was made, the statistically significant increase in the risk of retinopathy was observed in participants with the category of FPG ≥5.5 mmol/L or HbA1c ≥6.5% in comparison with participants in the category of the lowest FPG or HbA1c. However, this statistically significant increased risk of retinopathy remained only in participants with FPG ≥7.0 mmol/L or HbA1c ≥6.5% compared with participants with the lowest FPG or HbA1c after adjusting for age and SBP.

Bottom Line: The study comprises 1,864 Japanese who participated in the general health check-up program and did not have a previous history of cardiovascular disease.Non-mydriatic 45° digital fundus photographs were taken twice annually.However, a statistically significant increased risk of retinopathy remained only in participants with FPG ≥ 7.0 mmol/L or HbA1c ≥ 6.5% compared with those with the lowest quartile of glucose in the participants without previously diagnosed diabetes after adjusting for age and SBP.

View Article: PubMed Central - PubMed

Affiliation: Diabetes Center Tokyo Women's Medical University School of Medicine Tokyo Japan.

ABSTRACT

Aims/introduction: To determine the prevalence and risk factors of retinopathy and validity of the current diagnostic cut-offs for diabetes by using data of health check-up examinees.

Materials and methods: The study comprises 1,864 Japanese who participated in the general health check-up program and did not have a previous history of cardiovascular disease. Non-mydriatic 45° digital fundus photographs were taken twice annually. Multivariate logistic regression model was used to identify risk factors for retinopathy in participants without previously diagnosed diabetes.

Results: The overall prevalence of retinopathy in participants with and without previously diagnosed diabetes were 23.3% (28/120) and 4.2% (74/1,744), respectively. Univariate logistic regression analysis identified age, systolic blood pressure (SBP), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) as risk factors for retinopathy. Multivariate logistic regression analysis showed that FPG or both HbA1c and SBP were significant, positive and independent risk factors for retinopathy. The prevalence of retinopathy increased with deterioration of glucose categories (P < 0.001 for FPG or HbA1c). However, a statistically significant increased risk of retinopathy remained only in participants with FPG ≥ 7.0 mmol/L or HbA1c ≥ 6.5% compared with those with the lowest quartile of glucose in the participants without previously diagnosed diabetes after adjusting for age and SBP.

Conclusions: The prevalence of retinopathy was 4.2%, and FPG or both HbA1c and SBP were positive and independent risk factors for retinopathy in health check-up examinees without previously diagnosed diabetes. The FPG 7.0 mmol/L or HbA1c 6.5% seems to be appropriate to diagnose diabetes in view of its association with retinopathy.

No MeSH data available.


Related in: MedlinePlus