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The evaluation of interleukin-8 chemokine in chronic and acute Toxoplasma gondii infection.

Rostami Nejad M, Sherafat SJ, Roshani M, Telkabadi M, Lahmi F, Cheraghipour K, Kaboli AR, Alavi-Moghaddam M - Gastroenterol Hepatol Bed Bench (2011)

Bottom Line: ELISA was used to determine the level of IL8 in sera of 568 pregnant women.The level of IL8 in group I was within normal range similar to control group.The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T.gondii infection.

View Article: PubMed Central - PubMed

Affiliation: Research Institute of Gastroenterology and Liver Diseases, Shahid Beheshti University, M.C, Tehran, Iran.

ABSTRACT

Aim: We investigated whether the level of IL8 was different in patients with chronic and acute Toxoplasma gondii infection during the pregnancy compared with control group.

Background: It is well established that T.gondii infection induces a strong cell-mediated immune response.

Patients and methods: ELISA was used to determine the level of IL8 in sera of 568 pregnant women. Patients were divided into three groups according to a T.gondii serology. The first group included 202 women with positive IgG titres, the second group was 66 women with IgM and negative IgG T.gondii serology; and the third group comprised the sera of 300 healthy pregnant women with negative T.gondii serology and served as controls.

Results: The level of IL8 in group I was within normal range similar to control group. However, the level of IL8 was increased in those pregnant patients with positive IgM T.gondii serology.

Conclusion: The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T.gondii infection.

No MeSH data available.


Related in: MedlinePlus

The circulation of Toxoplasma gondii transmission form animals to pregnant women.
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Figure 0001: The circulation of Toxoplasma gondii transmission form animals to pregnant women.

Mentions: Most pregnant women with acute acquired infection do not experience obvious symptoms or signs (2). Acute and latent T.gondii infections during pregnancy are most commonly diagnosed by detecting the immunoglobulin IgG and IgM antibodies in the serum samples of the patients using enzyme-linked immunosorbent assay (ELISA) (Fig. 1) (3).


The evaluation of interleukin-8 chemokine in chronic and acute Toxoplasma gondii infection.

Rostami Nejad M, Sherafat SJ, Roshani M, Telkabadi M, Lahmi F, Cheraghipour K, Kaboli AR, Alavi-Moghaddam M - Gastroenterol Hepatol Bed Bench (2011)

The circulation of Toxoplasma gondii transmission form animals to pregnant women.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4017403&req=5

Figure 0001: The circulation of Toxoplasma gondii transmission form animals to pregnant women.
Mentions: Most pregnant women with acute acquired infection do not experience obvious symptoms or signs (2). Acute and latent T.gondii infections during pregnancy are most commonly diagnosed by detecting the immunoglobulin IgG and IgM antibodies in the serum samples of the patients using enzyme-linked immunosorbent assay (ELISA) (Fig. 1) (3).

Bottom Line: ELISA was used to determine the level of IL8 in sera of 568 pregnant women.The level of IL8 in group I was within normal range similar to control group.The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T.gondii infection.

View Article: PubMed Central - PubMed

Affiliation: Research Institute of Gastroenterology and Liver Diseases, Shahid Beheshti University, M.C, Tehran, Iran.

ABSTRACT

Aim: We investigated whether the level of IL8 was different in patients with chronic and acute Toxoplasma gondii infection during the pregnancy compared with control group.

Background: It is well established that T.gondii infection induces a strong cell-mediated immune response.

Patients and methods: ELISA was used to determine the level of IL8 in sera of 568 pregnant women. Patients were divided into three groups according to a T.gondii serology. The first group included 202 women with positive IgG titres, the second group was 66 women with IgM and negative IgG T.gondii serology; and the third group comprised the sera of 300 healthy pregnant women with negative T.gondii serology and served as controls.

Results: The level of IL8 in group I was within normal range similar to control group. However, the level of IL8 was increased in those pregnant patients with positive IgM T.gondii serology.

Conclusion: The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T.gondii infection.

No MeSH data available.


Related in: MedlinePlus