Limits...
Interactive 3D visualization of structural changes in the brain of a person with corticobasal syndrome.

Hänel C, Pieperhoff P, Hentschel B, Amunts K, Kuhlen T - Front Neuroinform (2014)

Bottom Line: Here, we present an application with two designs for the 3D visualization of the human brain to address these challenges.The application was developed to run in both, standard desktop environments and in immersive virtual reality environments with stereoscopic viewing for improving the depth perception.We conclude, that the presented application facilitates the perception of the extent of brain degeneration with respect to its localization and affected regions.

View Article: PubMed Central - PubMed

Affiliation: JARA - High Performance Computing, IT Center - Computational Science and Engineering, Computer Science Department, Virtual Reality Group, RWTH Aachen University Aachen, Germany.

ABSTRACT
The visualization of the progression of brain tissue loss in neurodegenerative diseases like corticobasal syndrome (CBS) can provide not only information about the localization and distribution of the volume loss, but also helps to understand the course and the causes of this neurodegenerative disorder. The visualization of such medical imaging data is often based on 2D sections, because they show both internal and external structures in one image. Spatial information, however, is lost. 3D visualization of imaging data is capable to solve this problem, but it faces the difficulty that more internally located structures may be occluded by structures near the surface. Here, we present an application with two designs for the 3D visualization of the human brain to address these challenges. In the first design, brain anatomy is displayed semi-transparently; it is supplemented by an anatomical section and cortical areas for spatial orientation, and the volumetric data of volume loss. The second design is guided by the principle of importance-driven volume rendering: A direct line-of-sight to the relevant structures in the deeper parts of the brain is provided by cutting out a frustum-like piece of brain tissue. The application was developed to run in both, standard desktop environments and in immersive virtual reality environments with stereoscopic viewing for improving the depth perception. We conclude, that the presented application facilitates the perception of the extent of brain degeneration with respect to its localization and affected regions.

No MeSH data available.


Related in: MedlinePlus

View dependent frustum-like cutout into the volume (light blue) following the depth structure of the VOI (dark blue).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4017140&req=5

Figure 2: View dependent frustum-like cutout into the volume (light blue) following the depth structure of the VOI (dark blue).

Mentions: Based on the previous findings we introduce two designs for the visualization of brain data with time dependant structural changes. The user interface of our visualization system had to enable an intuitive interaction and to provide an overview of the whole data in combination with detailed view of spatial relations of anatomical structures. The first design provides detailed anatomical information by means of a transparent anatomy of a whole MRI brain data set, whereby a 2D section can be interactively defined within this volume (cf. Figure 1). The second design extends the approach of Viola et al. (2004) by using a frustum of a cone as clipping object (cf. Figure 2) to provide more context information about nearby structures on the clipping planes (cf. Figure 3).


Interactive 3D visualization of structural changes in the brain of a person with corticobasal syndrome.

Hänel C, Pieperhoff P, Hentschel B, Amunts K, Kuhlen T - Front Neuroinform (2014)

View dependent frustum-like cutout into the volume (light blue) following the depth structure of the VOI (dark blue).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4017140&req=5

Figure 2: View dependent frustum-like cutout into the volume (light blue) following the depth structure of the VOI (dark blue).
Mentions: Based on the previous findings we introduce two designs for the visualization of brain data with time dependant structural changes. The user interface of our visualization system had to enable an intuitive interaction and to provide an overview of the whole data in combination with detailed view of spatial relations of anatomical structures. The first design provides detailed anatomical information by means of a transparent anatomy of a whole MRI brain data set, whereby a 2D section can be interactively defined within this volume (cf. Figure 1). The second design extends the approach of Viola et al. (2004) by using a frustum of a cone as clipping object (cf. Figure 2) to provide more context information about nearby structures on the clipping planes (cf. Figure 3).

Bottom Line: Here, we present an application with two designs for the 3D visualization of the human brain to address these challenges.The application was developed to run in both, standard desktop environments and in immersive virtual reality environments with stereoscopic viewing for improving the depth perception.We conclude, that the presented application facilitates the perception of the extent of brain degeneration with respect to its localization and affected regions.

View Article: PubMed Central - PubMed

Affiliation: JARA - High Performance Computing, IT Center - Computational Science and Engineering, Computer Science Department, Virtual Reality Group, RWTH Aachen University Aachen, Germany.

ABSTRACT
The visualization of the progression of brain tissue loss in neurodegenerative diseases like corticobasal syndrome (CBS) can provide not only information about the localization and distribution of the volume loss, but also helps to understand the course and the causes of this neurodegenerative disorder. The visualization of such medical imaging data is often based on 2D sections, because they show both internal and external structures in one image. Spatial information, however, is lost. 3D visualization of imaging data is capable to solve this problem, but it faces the difficulty that more internally located structures may be occluded by structures near the surface. Here, we present an application with two designs for the 3D visualization of the human brain to address these challenges. In the first design, brain anatomy is displayed semi-transparently; it is supplemented by an anatomical section and cortical areas for spatial orientation, and the volumetric data of volume loss. The second design is guided by the principle of importance-driven volume rendering: A direct line-of-sight to the relevant structures in the deeper parts of the brain is provided by cutting out a frustum-like piece of brain tissue. The application was developed to run in both, standard desktop environments and in immersive virtual reality environments with stereoscopic viewing for improving the depth perception. We conclude, that the presented application facilitates the perception of the extent of brain degeneration with respect to its localization and affected regions.

No MeSH data available.


Related in: MedlinePlus