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Obsessive-compulsive symptoms and their impacts on psychosocial functioning in people with epilepsy.

Seo JH, Lee WK, Park SP - J Clin Neurol (2014)

Bottom Line: The MOCI total score was significantly higher in PWE than in healthy controls (p=0.002).OCS were found in 20% of eligible patients.The MOCI total score directly affected the QOLIE-31 overall score and also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea.

ABSTRACT

Background and purpose: Obsessive-compulsive symptoms (OCS) in people with epilepsy (PWE) have not been studied systematically. We evaluated the severity, predictors, and psychosocial impact of OCS in PWE.

Methods: We recruited PWE who visited our epilepsy clinic and age-, gender-, and education-matched healthy controls. Both PWE and healthy controls completed the Maudsley Obsessional-Compulsive Inventory (MOCI), which measures OCS. PWE also completed the Beck Depression Inventory (BDI) and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31). We examined the severity of OCS in PWE relative to healthy controls. Predictors of OCS and the QOLIE-31 score were measured by regression analyses. A path analysis model was constructed to verify interrelations between the variables.

Results: The MOCI total score was significantly higher in PWE than in healthy controls (p=0.002). OCS were found in 20% of eligible patients. The strongest predictor of the MOCI total score was the BDI score (β=0.417, p<0.001), followed by EEG abnormality (β=0.194, p<0.001) and etiology (β=0.107, p=0.031). Epileptic syndrome, the side of the epileptic focus, and action mechanisms of antiepileptic drugs did not affect the MOCI total score. The strongest predictor of the QOLIE-31 overall score was the BDI score (β=-0.569, p<0.001), followed by seizure control (β=-0.163, p<0.001) and the MOCI total score (β=-0.148, p=0.001). The MOCI total score directly affected the QOLIE-31 overall score and also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.

Conclusions: OCS are more likely to develop in PWE than in healthy people. The development of OCS appears to elicit psychosocial problems directly or indirectly by provoking depression or uncontrolled seizures.

No MeSH data available.


Related in: MedlinePlus

Interrelations between clinical variables and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) overall score by a refined path analysis model. An arrow indicates a direct relationship from one variable to another. Numbers denote standardized regression coefficients (β weights) for each path. Negative coefficients indicate that when the predictor variable score increases by one standard deviation, the QOLIE-31 overall score decreases by the number of standard deviations equal to the value of the coefficient. BDI: Beck Depression Inventory, MOCI: Maudsley Obsessional-Compulsive Inventory.
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Figure 1: Interrelations between clinical variables and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) overall score by a refined path analysis model. An arrow indicates a direct relationship from one variable to another. Numbers denote standardized regression coefficients (β weights) for each path. Negative coefficients indicate that when the predictor variable score increases by one standard deviation, the QOLIE-31 overall score decreases by the number of standard deviations equal to the value of the coefficient. BDI: Beck Depression Inventory, MOCI: Maudsley Obsessional-Compulsive Inventory.

Mentions: Complex interrelations between predictors and the QOLIE-31 overall score are illustrated by the refined path analysis model in Fig. 1. According to predefined criteria, the final model provided an acceptable fit to the data (χ2=23.91, p<0.001; NFI=0.950, CFI=0.950, GFI=0.970, and RMR=0.080). The MOCI total score, seizure control, and BDI score were found to exert direct effects on the QOLIE-31 overall score. The MOCI total score also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.


Obsessive-compulsive symptoms and their impacts on psychosocial functioning in people with epilepsy.

Seo JH, Lee WK, Park SP - J Clin Neurol (2014)

Interrelations between clinical variables and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) overall score by a refined path analysis model. An arrow indicates a direct relationship from one variable to another. Numbers denote standardized regression coefficients (β weights) for each path. Negative coefficients indicate that when the predictor variable score increases by one standard deviation, the QOLIE-31 overall score decreases by the number of standard deviations equal to the value of the coefficient. BDI: Beck Depression Inventory, MOCI: Maudsley Obsessional-Compulsive Inventory.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4017015&req=5

Figure 1: Interrelations between clinical variables and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) overall score by a refined path analysis model. An arrow indicates a direct relationship from one variable to another. Numbers denote standardized regression coefficients (β weights) for each path. Negative coefficients indicate that when the predictor variable score increases by one standard deviation, the QOLIE-31 overall score decreases by the number of standard deviations equal to the value of the coefficient. BDI: Beck Depression Inventory, MOCI: Maudsley Obsessional-Compulsive Inventory.
Mentions: Complex interrelations between predictors and the QOLIE-31 overall score are illustrated by the refined path analysis model in Fig. 1. According to predefined criteria, the final model provided an acceptable fit to the data (χ2=23.91, p<0.001; NFI=0.950, CFI=0.950, GFI=0.970, and RMR=0.080). The MOCI total score, seizure control, and BDI score were found to exert direct effects on the QOLIE-31 overall score. The MOCI total score also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.

Bottom Line: The MOCI total score was significantly higher in PWE than in healthy controls (p=0.002).OCS were found in 20% of eligible patients.The MOCI total score directly affected the QOLIE-31 overall score and also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea.

ABSTRACT

Background and purpose: Obsessive-compulsive symptoms (OCS) in people with epilepsy (PWE) have not been studied systematically. We evaluated the severity, predictors, and psychosocial impact of OCS in PWE.

Methods: We recruited PWE who visited our epilepsy clinic and age-, gender-, and education-matched healthy controls. Both PWE and healthy controls completed the Maudsley Obsessional-Compulsive Inventory (MOCI), which measures OCS. PWE also completed the Beck Depression Inventory (BDI) and the Quality of Life in Epilepsy Inventory-31 (QOLIE-31). We examined the severity of OCS in PWE relative to healthy controls. Predictors of OCS and the QOLIE-31 score were measured by regression analyses. A path analysis model was constructed to verify interrelations between the variables.

Results: The MOCI total score was significantly higher in PWE than in healthy controls (p=0.002). OCS were found in 20% of eligible patients. The strongest predictor of the MOCI total score was the BDI score (β=0.417, p<0.001), followed by EEG abnormality (β=0.194, p<0.001) and etiology (β=0.107, p=0.031). Epileptic syndrome, the side of the epileptic focus, and action mechanisms of antiepileptic drugs did not affect the MOCI total score. The strongest predictor of the QOLIE-31 overall score was the BDI score (β=-0.569, p<0.001), followed by seizure control (β=-0.163, p<0.001) and the MOCI total score (β=-0.148, p=0.001). The MOCI total score directly affected the QOLIE-31 overall score and also exerted indirect effects on the QOLIE-31 overall score through seizure control and the BDI score.

Conclusions: OCS are more likely to develop in PWE than in healthy people. The development of OCS appears to elicit psychosocial problems directly or indirectly by provoking depression or uncontrolled seizures.

No MeSH data available.


Related in: MedlinePlus