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"En-face" spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome.

De Bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel JA, Mauget-Faÿsse M - J Ophthalmol (2014)

Bottom Line: The match between autofluorescence imaging, indocyanine green angiography, and "en-face" OCT helped identify the acute microstructural damages in the outer retina further than the choroid.Follow-up using "en-face" EDI-OCT revealed progressive and complete recovery of the central outer retinal layers.Moreover, "en-face" OCT is helpful in the follow-up of these lesions by being able to show the recovery of the outer retinal layers.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Medicine Lyon 1, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.

ABSTRACT
Purpose. The recent use of "en-face" enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods. Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan ("en-face") EDI SD-OCT at the initial visit and during follow-up. Results. C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and "en-face" OCT helped identify the acute microstructural damages in the outer retina further than the choroid. Follow-up using "en-face" EDI-OCT revealed progressive and complete recovery of the central outer retinal layers. Conclusion. "En-face" EDI SD-OCT identified the site of initial damage in MEWDS as the photoreceptors and the interdigitation layers rather than the choroid. Moreover, "en-face" OCT is helpful in the follow-up of these lesions by being able to show the recovery of the outer retinal layers.

No MeSH data available.


Related in: MedlinePlus

(a) “En-face” EDI SD-OCT, at the level of the ellipsoid zone in the acute phase, showing hyporeflective areas. (b) “En-face” EDI SD-OCT, at the level of the ellipsoid zone at 6-month follow-up, showing incomplete recovery of the ellipsoid zone.
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fig6: (a) “En-face” EDI SD-OCT, at the level of the ellipsoid zone in the acute phase, showing hyporeflective areas. (b) “En-face” EDI SD-OCT, at the level of the ellipsoid zone at 6-month follow-up, showing incomplete recovery of the ellipsoid zone.

Mentions: Mean follow-up of the study patients was 6 months. As classically described, all the patients included in this study had a spontaneous resolution within a few weeks without treatment. Visual acuity at the final visit was 20/20 in all patients. “En-face” OCT demonstrated a progressive and incomplete recovery of the ellipsoid zone. Disappearance of the hyperreflective lesions located in the outer nuclear layer could also be observed (Figure 6). After 6 months of follow-up, the retrofoveolar choroidal thickness in B-EDI-OCT scans was nearly the same with a mean of 370 μm.


"En-face" spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome.

De Bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel JA, Mauget-Faÿsse M - J Ophthalmol (2014)

(a) “En-face” EDI SD-OCT, at the level of the ellipsoid zone in the acute phase, showing hyporeflective areas. (b) “En-face” EDI SD-OCT, at the level of the ellipsoid zone at 6-month follow-up, showing incomplete recovery of the ellipsoid zone.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4016932&req=5

fig6: (a) “En-face” EDI SD-OCT, at the level of the ellipsoid zone in the acute phase, showing hyporeflective areas. (b) “En-face” EDI SD-OCT, at the level of the ellipsoid zone at 6-month follow-up, showing incomplete recovery of the ellipsoid zone.
Mentions: Mean follow-up of the study patients was 6 months. As classically described, all the patients included in this study had a spontaneous resolution within a few weeks without treatment. Visual acuity at the final visit was 20/20 in all patients. “En-face” OCT demonstrated a progressive and incomplete recovery of the ellipsoid zone. Disappearance of the hyperreflective lesions located in the outer nuclear layer could also be observed (Figure 6). After 6 months of follow-up, the retrofoveolar choroidal thickness in B-EDI-OCT scans was nearly the same with a mean of 370 μm.

Bottom Line: The match between autofluorescence imaging, indocyanine green angiography, and "en-face" OCT helped identify the acute microstructural damages in the outer retina further than the choroid.Follow-up using "en-face" EDI-OCT revealed progressive and complete recovery of the central outer retinal layers.Moreover, "en-face" OCT is helpful in the follow-up of these lesions by being able to show the recovery of the outer retinal layers.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Medicine Lyon 1, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.

ABSTRACT
Purpose. The recent use of "en-face" enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods. Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan ("en-face") EDI SD-OCT at the initial visit and during follow-up. Results. C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and "en-face" OCT helped identify the acute microstructural damages in the outer retina further than the choroid. Follow-up using "en-face" EDI-OCT revealed progressive and complete recovery of the central outer retinal layers. Conclusion. "En-face" EDI SD-OCT identified the site of initial damage in MEWDS as the photoreceptors and the interdigitation layers rather than the choroid. Moreover, "en-face" OCT is helpful in the follow-up of these lesions by being able to show the recovery of the outer retinal layers.

No MeSH data available.


Related in: MedlinePlus