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The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.

Wang YJ, Hsu YW, Chang CM, Wu CC, Ou JC, Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY - Biomed Res Int (2014)

Bottom Line: In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI.Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury.Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.

ABSTRACT
Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.

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Dizziness rate among mTBI patients stratified by rs35697037.
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fig3: Dizziness rate among mTBI patients stratified by rs35697037.

Mentions: We further analyzed the association of BMX SNPs and symptoms in mTBI patients. As shown in Table 5, mTBI patients with TT and CT genotypes (57.0 ± 46.7) of rs16979956 had higher dizziness handicap inventory (DHI) scores than patients with the CC genotype (25.7 ± 21.5) during the first week (P value = 0.0445). In addition, we found another SNP (rs35697037) at the same intronic region that also had a propensity to affect the DHI score (P value = 0.0738). However, we found no significant association between BMX polymorphisms and DHI score after six weeks. To validate this result, we examined the dizziness rate from nurses' recordings. As shown in Figure 3, the AA and AG genotypes (70.6%) of SNP (rs35697037) carriers were significantly associated with a higher incidence of dizziness than GG (53.0%) genotype carriers within the first week (P value = 0.0122). However, we failed to find a significant correlation between the other SNPs of BMX and the occurrence rate of dizziness (data not shown).


The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.

Wang YJ, Hsu YW, Chang CM, Wu CC, Ou JC, Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY - Biomed Res Int (2014)

Dizziness rate among mTBI patients stratified by rs35697037.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016905&req=5

fig3: Dizziness rate among mTBI patients stratified by rs35697037.
Mentions: We further analyzed the association of BMX SNPs and symptoms in mTBI patients. As shown in Table 5, mTBI patients with TT and CT genotypes (57.0 ± 46.7) of rs16979956 had higher dizziness handicap inventory (DHI) scores than patients with the CC genotype (25.7 ± 21.5) during the first week (P value = 0.0445). In addition, we found another SNP (rs35697037) at the same intronic region that also had a propensity to affect the DHI score (P value = 0.0738). However, we found no significant association between BMX polymorphisms and DHI score after six weeks. To validate this result, we examined the dizziness rate from nurses' recordings. As shown in Figure 3, the AA and AG genotypes (70.6%) of SNP (rs35697037) carriers were significantly associated with a higher incidence of dizziness than GG (53.0%) genotype carriers within the first week (P value = 0.0122). However, we failed to find a significant correlation between the other SNPs of BMX and the occurrence rate of dizziness (data not shown).

Bottom Line: In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI.Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury.Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.

ABSTRACT
Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.

Show MeSH
Related in: MedlinePlus