Limits...
The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.

Wang YJ, Hsu YW, Chang CM, Wu CC, Ou JC, Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY - Biomed Res Int (2014)

Bottom Line: In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI.Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury.Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.

ABSTRACT
Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.

Show MeSH

Related in: MedlinePlus

Differential serum BMX level between mTBI patients and controls.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4016905&req=5

fig1: Differential serum BMX level between mTBI patients and controls.

Mentions: Initially, we compared serum BMX levels in a total of 51 mTBI patients and 54 controls. The mean serum level of BMX was higher in mTBI patients (7.47 μg/L) than in healthy controls (6.08 μg/L) (Figure 1). The characteristics of these subjects are shown in Table 1. The mean patient age was 42.3 in mTBI patients and 30.9 in the controls. The percentage of females was different between mTBI patients and control groups (66.7% and 59.3%, resp.). Our data revealed that 27.5% of the mTBI patients suffered from headache, which was slightly higher than controls (20.4%). Of note, the mTBI patients had a higher depression symptoms rating (54.9%) than control subjects (16.7%), and the result was consistent with BDI scores. In addition, mTBI patients had higher DHI scores, which reflected the effects of dizziness on their quality of life.


The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.

Wang YJ, Hsu YW, Chang CM, Wu CC, Ou JC, Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY - Biomed Res Int (2014)

Differential serum BMX level between mTBI patients and controls.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016905&req=5

fig1: Differential serum BMX level between mTBI patients and controls.
Mentions: Initially, we compared serum BMX levels in a total of 51 mTBI patients and 54 controls. The mean serum level of BMX was higher in mTBI patients (7.47 μg/L) than in healthy controls (6.08 μg/L) (Figure 1). The characteristics of these subjects are shown in Table 1. The mean patient age was 42.3 in mTBI patients and 30.9 in the controls. The percentage of females was different between mTBI patients and control groups (66.7% and 59.3%, resp.). Our data revealed that 27.5% of the mTBI patients suffered from headache, which was slightly higher than controls (20.4%). Of note, the mTBI patients had a higher depression symptoms rating (54.9%) than control subjects (16.7%), and the result was consistent with BDI scores. In addition, mTBI patients had higher DHI scores, which reflected the effects of dizziness on their quality of life.

Bottom Line: In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI.Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury.Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.

ABSTRACT
Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients suffer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes after TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. Therefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the first week after head injury. Additionally, another SNP, rs35697037, showed a significant correlation with dizziness symptoms. These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI.

Show MeSH
Related in: MedlinePlus