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The interaction pattern between a homology model of 40S ribosomal S9 protein of Rhizoctonia solani and 1-hydroxyphenaize by docking study.

Dharni S - Biomed Res Int (2014)

Bottom Line: 1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani.In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein.Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.

View Article: PubMed Central - PubMed

Affiliation: Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.

ABSTRACT
1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.

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Antifungal activity of 1-hydroxyphenazine at 40 μg/disc against Rhizoctonia solani.
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fig1: Antifungal activity of 1-hydroxyphenazine at 40 μg/disc against Rhizoctonia solani.

Mentions: Our previous studies demonstrated that 1-OH-PHZ showed antifungal activity against R. solani, a soilborne pathogen, at 40 μg/disc (Figure 1) [19]. 1-OH-PHZ earlier isolated from P. aeruginosa TISTR 781 [26] was reported to inhibit Escherichia coli and Xanthomonas campestris pv. vesicatoria. Recently, phenazine-1-carboxylic acid (PCA) produced by Pseudomonas sp. M18G is being marketed as Shenquinmycin in China, which has gained a Pesticide Registration Certification (Fusarium oxysporum) issued by the Chinese Ministry of Agriculture, owing to its high efficiency against various phytopathogens, low toxicity, and good environmental compatibility. It is proved as an effective agent for the biocontrol of withering of watermelon sprout (code) and piemintoepidemic disease (Pythium capsici) [27, 28]. 1-OH-PHZ was earlier isolated from P. aeruginosa TISTR 781 and known to inhibit Escherichia coli and Xanthomonas campestris pv. vesicatoria [26]. N-acrylamides of 9-substituted phenazine-1-carboxylic acids (PCA) have been reported as strong inhibitors of RNA synthesis [29, 30].


The interaction pattern between a homology model of 40S ribosomal S9 protein of Rhizoctonia solani and 1-hydroxyphenaize by docking study.

Dharni S - Biomed Res Int (2014)

Antifungal activity of 1-hydroxyphenazine at 40 μg/disc against Rhizoctonia solani.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016899&req=5

fig1: Antifungal activity of 1-hydroxyphenazine at 40 μg/disc against Rhizoctonia solani.
Mentions: Our previous studies demonstrated that 1-OH-PHZ showed antifungal activity against R. solani, a soilborne pathogen, at 40 μg/disc (Figure 1) [19]. 1-OH-PHZ earlier isolated from P. aeruginosa TISTR 781 [26] was reported to inhibit Escherichia coli and Xanthomonas campestris pv. vesicatoria. Recently, phenazine-1-carboxylic acid (PCA) produced by Pseudomonas sp. M18G is being marketed as Shenquinmycin in China, which has gained a Pesticide Registration Certification (Fusarium oxysporum) issued by the Chinese Ministry of Agriculture, owing to its high efficiency against various phytopathogens, low toxicity, and good environmental compatibility. It is proved as an effective agent for the biocontrol of withering of watermelon sprout (code) and piemintoepidemic disease (Pythium capsici) [27, 28]. 1-OH-PHZ was earlier isolated from P. aeruginosa TISTR 781 and known to inhibit Escherichia coli and Xanthomonas campestris pv. vesicatoria [26]. N-acrylamides of 9-substituted phenazine-1-carboxylic acids (PCA) have been reported as strong inhibitors of RNA synthesis [29, 30].

Bottom Line: 1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani.In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein.Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.

View Article: PubMed Central - PubMed

Affiliation: Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.

ABSTRACT
1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.

Show MeSH
Related in: MedlinePlus