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Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus

FNDC5/irisin detection on human adipose tissue. Representative immunoblot detection of FNDC5/irisin in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) biopsies from NW and OB subjects (a); FNDC5/irisin immunodetection in human SAT and VAT biopsies and their secretome from OB individuals (b).
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fig4: FNDC5/irisin detection on human adipose tissue. Representative immunoblot detection of FNDC5/irisin in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) biopsies from NW and OB subjects (a); FNDC5/irisin immunodetection in human SAT and VAT biopsies and their secretome from OB individuals (b).

Mentions: In order to assay the participation of adipose tissue on irisin circulating levels, the immunodetection of this protein was tested on adipose tissue biopsies from healthy and obese individuals. As shown in Figure 4, FNDC5/irisin was detected on visceral and subcutaneous adipose tissue secretion from NW and OB individuals (Figure 4(a)) and in OB at both intracellular and secretion level (Figure 4(b)).


Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

FNDC5/irisin detection on human adipose tissue. Representative immunoblot detection of FNDC5/irisin in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) biopsies from NW and OB subjects (a); FNDC5/irisin immunodetection in human SAT and VAT biopsies and their secretome from OB individuals (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4016898&req=5

fig4: FNDC5/irisin detection on human adipose tissue. Representative immunoblot detection of FNDC5/irisin in human visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) biopsies from NW and OB subjects (a); FNDC5/irisin immunodetection in human SAT and VAT biopsies and their secretome from OB individuals (b).
Mentions: In order to assay the participation of adipose tissue on irisin circulating levels, the immunodetection of this protein was tested on adipose tissue biopsies from healthy and obese individuals. As shown in Figure 4, FNDC5/irisin was detected on visceral and subcutaneous adipose tissue secretion from NW and OB individuals (Figure 4(a)) and in OB at both intracellular and secretion level (Figure 4(b)).

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus