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Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus

Daily physical activity and resting energy expenditure and its correlation with irisin. The average daily physical activity (units/day) and resting energy expenditure (REE: kcal/day) for the AN, NW, and OB subjects are shown in (a) and (b), respectively. Asterisk ( *P < 0.05 and  ***P < 0.001) denotes statistically significant differences between normal weight and anorexia nervosa or obesity versus anorexia nervosa and normal weight. The correlations between the circulating irisin and the daily physical activity and REE for the three groups are presented in (c) and (d).
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fig3: Daily physical activity and resting energy expenditure and its correlation with irisin. The average daily physical activity (units/day) and resting energy expenditure (REE: kcal/day) for the AN, NW, and OB subjects are shown in (a) and (b), respectively. Asterisk ( *P < 0.05 and  ***P < 0.001) denotes statistically significant differences between normal weight and anorexia nervosa or obesity versus anorexia nervosa and normal weight. The correlations between the circulating irisin and the daily physical activity and REE for the three groups are presented in (c) and (d).

Mentions: Because irisin secretion was shown to be induced by exercise and energy expenditure [7], the daily physical activity and resting energy expenditure (REE) were evaluated in the three BMI groups. The Actiwatch analysis in the OB subjects exhibited statistically lower daily physical activity with higher resting energy expenditure (REE) compared with the NW subjects adjusted by age (Figures 3(a) and 3(b), resp.). Therefore, the OB subjects exhibited higher daily physical activity compared with the extreme AN hospitalized subjects displaying very limited activity but lower activity compared with the NW subjects (P < 0.05). Obesity was accompanied by increased REE compared with the AN and NW subjects (P < 0.05). The plasma irisin levels were inversely correlated with daily physical activity (r = −0.22; P = 0.001) and directly correlated with REE (Figures 3(c) and 3(d)). After adjusting by the BMI group, only the association between irisin and REE was maintained (r = 0.34; P = 0.001), and the daily physical activity was not statistically significant (r = −0.06; P = 0.432).


Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Daily physical activity and resting energy expenditure and its correlation with irisin. The average daily physical activity (units/day) and resting energy expenditure (REE: kcal/day) for the AN, NW, and OB subjects are shown in (a) and (b), respectively. Asterisk ( *P < 0.05 and  ***P < 0.001) denotes statistically significant differences between normal weight and anorexia nervosa or obesity versus anorexia nervosa and normal weight. The correlations between the circulating irisin and the daily physical activity and REE for the three groups are presented in (c) and (d).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4016898&req=5

fig3: Daily physical activity and resting energy expenditure and its correlation with irisin. The average daily physical activity (units/day) and resting energy expenditure (REE: kcal/day) for the AN, NW, and OB subjects are shown in (a) and (b), respectively. Asterisk ( *P < 0.05 and  ***P < 0.001) denotes statistically significant differences between normal weight and anorexia nervosa or obesity versus anorexia nervosa and normal weight. The correlations between the circulating irisin and the daily physical activity and REE for the three groups are presented in (c) and (d).
Mentions: Because irisin secretion was shown to be induced by exercise and energy expenditure [7], the daily physical activity and resting energy expenditure (REE) were evaluated in the three BMI groups. The Actiwatch analysis in the OB subjects exhibited statistically lower daily physical activity with higher resting energy expenditure (REE) compared with the NW subjects adjusted by age (Figures 3(a) and 3(b), resp.). Therefore, the OB subjects exhibited higher daily physical activity compared with the extreme AN hospitalized subjects displaying very limited activity but lower activity compared with the NW subjects (P < 0.05). Obesity was accompanied by increased REE compared with the AN and NW subjects (P < 0.05). The plasma irisin levels were inversely correlated with daily physical activity (r = −0.22; P = 0.001) and directly correlated with REE (Figures 3(c) and 3(d)). After adjusting by the BMI group, only the association between irisin and REE was maintained (r = 0.34; P = 0.001), and the daily physical activity was not statistically significant (r = −0.06; P = 0.432).

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus