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Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus

Correlation of circulating irisin with fat mass and fat-free mass. Plasma irisin correlation with fat mass (kg), fat mass (%), fat-free mass (kg), and fat-free mass (%) for the three groups (NW, AN, and OB) is shown.
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fig2: Correlation of circulating irisin with fat mass and fat-free mass. Plasma irisin correlation with fat mass (kg), fat mass (%), fat-free mass (kg), and fat-free mass (%) for the three groups (NW, AN, and OB) is shown.

Mentions: Further analysis showed that the irisin levels were positively correlated with two parameters of adiposity (i.e., body weight (r = 0.52; P < 0.001) and BMI (r = 0.52; P < 0.001)). The irisin plasma levels were not correlated with height (r = −0.05; P > 0.05). The correlations indicated that irisin strongly reflects the body fat mass component, which is further supported by the bioelectrical impedance analysis of body composition in which the irisin plasma levels correlated with the fat mass measured in kg (r = 0.52; P = 0.001; Figure 2) and the percentage of fat mass (r = 0.48; P < 0.001). However, the muscle component may also contribute to irisin circulating levels as shown by the positive correlation between irisin and fat-free mass (r = 0.43; P = 0.001; Figure 2). An inverse correlation was observed between the irisin levels and the percentage of fat-free mass (r = −0.53; P < 0.001). The associations between irisin and fat mass and fat-free mass were maintained after adjusting for the studied groups (data not shown). In addition, a direct association was observed between plasmatic levels of irisin and glucose (r = 0.22; P = 0.0026), insulin (r = 0.34: P < 0.001), and HOMA-IR (r = 0.33; P = 0.001). This positive association was maintained especially for insulin and HOMA-IR after adjusting for the studied groups.


Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Correlation of circulating irisin with fat mass and fat-free mass. Plasma irisin correlation with fat mass (kg), fat mass (%), fat-free mass (kg), and fat-free mass (%) for the three groups (NW, AN, and OB) is shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4016898&req=5

fig2: Correlation of circulating irisin with fat mass and fat-free mass. Plasma irisin correlation with fat mass (kg), fat mass (%), fat-free mass (kg), and fat-free mass (%) for the three groups (NW, AN, and OB) is shown.
Mentions: Further analysis showed that the irisin levels were positively correlated with two parameters of adiposity (i.e., body weight (r = 0.52; P < 0.001) and BMI (r = 0.52; P < 0.001)). The irisin plasma levels were not correlated with height (r = −0.05; P > 0.05). The correlations indicated that irisin strongly reflects the body fat mass component, which is further supported by the bioelectrical impedance analysis of body composition in which the irisin plasma levels correlated with the fat mass measured in kg (r = 0.52; P = 0.001; Figure 2) and the percentage of fat mass (r = 0.48; P < 0.001). However, the muscle component may also contribute to irisin circulating levels as shown by the positive correlation between irisin and fat-free mass (r = 0.43; P = 0.001; Figure 2). An inverse correlation was observed between the irisin levels and the percentage of fat-free mass (r = −0.53; P < 0.001). The associations between irisin and fat mass and fat-free mass were maintained after adjusting for the studied groups (data not shown). In addition, a direct association was observed between plasmatic levels of irisin and glucose (r = 0.22; P = 0.0026), insulin (r = 0.34: P < 0.001), and HOMA-IR (r = 0.33; P = 0.001). This positive association was maintained especially for insulin and HOMA-IR after adjusting for the studied groups.

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus