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Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus

Body composition and plasma irisin circulating levels. Body weight (kg), fat mass (kg), fat-free mass (kg), fat mass (%), and fat-free mass (%) are shown in the anorexia nervosa, normal weight, and obese groups. (a) Plasma irisin concentration in the three experimental groups (b). The data are shown as the mean (SE). Statistically significant differences are denoted as (a) P < 0.001 versus anorexia nervosa and (b) P < 0.001 versus normal weight and anorexia nervosa.
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fig1: Body composition and plasma irisin circulating levels. Body weight (kg), fat mass (kg), fat-free mass (kg), fat mass (%), and fat-free mass (%) are shown in the anorexia nervosa, normal weight, and obese groups. (a) Plasma irisin concentration in the three experimental groups (b). The data are shown as the mean (SE). Statistically significant differences are denoted as (a) P < 0.001 versus anorexia nervosa and (b) P < 0.001 versus normal weight and anorexia nervosa.

Mentions: As expected, the OB subjects exhibited higher body weight with higher fat mass and fat-free mass compared with the AN and NW subjects, with the differences being statistically significant after adjusting by age (Figure 1(a)). The NW subjects exhibited statistically higher body weight compared with the AN subjects accompanied by higher fat mass and fat-free mass. Considering the body composition as a percentage of the total body weight, the AN subjects exhibited higher fat-free mass than the NW and OB subjects (Figure 1(a)).


Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.

Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF - Int J Endocrinol (2014)

Body composition and plasma irisin circulating levels. Body weight (kg), fat mass (kg), fat-free mass (kg), fat mass (%), and fat-free mass (%) are shown in the anorexia nervosa, normal weight, and obese groups. (a) Plasma irisin concentration in the three experimental groups (b). The data are shown as the mean (SE). Statistically significant differences are denoted as (a) P < 0.001 versus anorexia nervosa and (b) P < 0.001 versus normal weight and anorexia nervosa.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4016898&req=5

fig1: Body composition and plasma irisin circulating levels. Body weight (kg), fat mass (kg), fat-free mass (kg), fat mass (%), and fat-free mass (%) are shown in the anorexia nervosa, normal weight, and obese groups. (a) Plasma irisin concentration in the three experimental groups (b). The data are shown as the mean (SE). Statistically significant differences are denoted as (a) P < 0.001 versus anorexia nervosa and (b) P < 0.001 versus normal weight and anorexia nervosa.
Mentions: As expected, the OB subjects exhibited higher body weight with higher fat mass and fat-free mass compared with the AN and NW subjects, with the differences being statistically significant after adjusting by age (Figure 1(a)). The NW subjects exhibited statistically higher body weight compared with the AN subjects accompanied by higher fat mass and fat-free mass. Considering the body composition as a percentage of the total body weight, the AN subjects exhibited higher fat-free mass than the NW and OB subjects (Figure 1(a)).

Bottom Line: The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients.The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, Spain ; CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain ; Obesidómica Group, Laboratory 3, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain.

ABSTRACT
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.

No MeSH data available.


Related in: MedlinePlus