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Cerebral endothelial function determined by cerebrovascular reactivity to L-arginine.

Pretnar-Oblak J - Biomed Res Int (2014)

Bottom Line: So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc.In addition CVR-L-Arg has also proven its usefulness in order to show potential improvement after pharmacological interventions.In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions.

View Article: PubMed Central - PubMed

Affiliation: Department for Vascular Neurology, Ljubljana Medical Centre, Zaloska 2, 1000 Ljubljana, Slovenia.

ABSTRACT
Endothelium forms the inner cellular lining of blood vessels and plays an important role in many physiological functions including the control of vasomotor tone. Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. Transcranial Doppler sonography is used for evaluation of cerebral blood flow changes. The method is noninvasive, inexpensive, and enables reproducible measurements. CVR-L-Arg has been compared to flow-mediated dilatation as a gold standard for systemic endothelial function and intima-media thickness as a marker for morphological changes. However, it seems to show specific cerebral endothelial function. So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. In addition CVR-L-Arg has also proven its usefulness in order to show potential improvement after pharmacological interventions. In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions.

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NO synthesis and its role.
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fig1: NO synthesis and its role.

Mentions: Endothelium-derived NO is constantly released in baseline quantities, but different stimuli dynamically augment its formation. After being released, NO passes to nearby vascular smooth muscle and other cells. Its action is short-lived due to quick inactivation. In the target cells, NO activates guanylate cyclase (GC) and thence intracellular concentration of cyclic guanosine monophosphate (cGMP) rises. Elevated level of cGMP leads to reduced intracellular concentration of calcium (Ca2+) in the vascular smooth muscle cells with resultant vasodilatation (Figure 1).


Cerebral endothelial function determined by cerebrovascular reactivity to L-arginine.

Pretnar-Oblak J - Biomed Res Int (2014)

NO synthesis and its role.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016874&req=5

fig1: NO synthesis and its role.
Mentions: Endothelium-derived NO is constantly released in baseline quantities, but different stimuli dynamically augment its formation. After being released, NO passes to nearby vascular smooth muscle and other cells. Its action is short-lived due to quick inactivation. In the target cells, NO activates guanylate cyclase (GC) and thence intracellular concentration of cyclic guanosine monophosphate (cGMP) rises. Elevated level of cGMP leads to reduced intracellular concentration of calcium (Ca2+) in the vascular smooth muscle cells with resultant vasodilatation (Figure 1).

Bottom Line: So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc.In addition CVR-L-Arg has also proven its usefulness in order to show potential improvement after pharmacological interventions.In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions.

View Article: PubMed Central - PubMed

Affiliation: Department for Vascular Neurology, Ljubljana Medical Centre, Zaloska 2, 1000 Ljubljana, Slovenia.

ABSTRACT
Endothelium forms the inner cellular lining of blood vessels and plays an important role in many physiological functions including the control of vasomotor tone. Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. Transcranial Doppler sonography is used for evaluation of cerebral blood flow changes. The method is noninvasive, inexpensive, and enables reproducible measurements. CVR-L-Arg has been compared to flow-mediated dilatation as a gold standard for systemic endothelial function and intima-media thickness as a marker for morphological changes. However, it seems to show specific cerebral endothelial function. So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. In addition CVR-L-Arg has also proven its usefulness in order to show potential improvement after pharmacological interventions. In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions.

Show MeSH
Related in: MedlinePlus