Limits...
Hyperglycemia, a neglected factor during cancer progression.

Duan W, Shen X, Lei J, Xu Q, Yu Y, Li R, Wu E, Ma Q - Biomed Res Int (2014)

Bottom Line: However, to date, the potential reasons for this association remain unclear.Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected.In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.

ABSTRACT
Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for this association remain unclear. Hyperglycemia, the most important feature of diabetes, may be responsible for the excess glucose supply for these glucose-hungry cells, and it contributes to apoptosis resistance, oncogenesis, and tumor cell resistance to chemotherapy. Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected. In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance. Therefore, controlling hyperglycemia may have important therapeutic implications in cancer patients.

Show MeSH

Related in: MedlinePlus

Hyperglycemia contributes to malignant cancer cell phenotypes. There is increasing evidence suggesting that there is a link between cancer and diabetes mellitus. Regardless of other shared metabolic factors, hyperglycemia, the most typical characteristic of diabetes, may be one reason to explain the prevalence of cancer incidence in patients with diabetes mellitus. Research shows that hyperglycemia may contribute to an enhanced proliferation ability, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4016871&req=5

fig1: Hyperglycemia contributes to malignant cancer cell phenotypes. There is increasing evidence suggesting that there is a link between cancer and diabetes mellitus. Regardless of other shared metabolic factors, hyperglycemia, the most typical characteristic of diabetes, may be one reason to explain the prevalence of cancer incidence in patients with diabetes mellitus. Research shows that hyperglycemia may contribute to an enhanced proliferation ability, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance.

Mentions: Increasing evidence suggests a close association between diabetes and various malignancies; however, the potential biologic links between the two diseases are incompletely understood. Given that hyperglycemia is the most important biological feature of DM and cancer that are composed of glucose-hungry cells, it is not hard to imagine that hyperglycemia may play an important role during cancer progression in cancer patients with DM. Here, we review the available evidence of the relationship between hyperglycemia and different biological characteristics of cancer. It appears that hyperglycemia may contribute to a more malignant phenotype of cancer cells, including proliferation, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance (Figure 1).


Hyperglycemia, a neglected factor during cancer progression.

Duan W, Shen X, Lei J, Xu Q, Yu Y, Li R, Wu E, Ma Q - Biomed Res Int (2014)

Hyperglycemia contributes to malignant cancer cell phenotypes. There is increasing evidence suggesting that there is a link between cancer and diabetes mellitus. Regardless of other shared metabolic factors, hyperglycemia, the most typical characteristic of diabetes, may be one reason to explain the prevalence of cancer incidence in patients with diabetes mellitus. Research shows that hyperglycemia may contribute to an enhanced proliferation ability, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016871&req=5

fig1: Hyperglycemia contributes to malignant cancer cell phenotypes. There is increasing evidence suggesting that there is a link between cancer and diabetes mellitus. Regardless of other shared metabolic factors, hyperglycemia, the most typical characteristic of diabetes, may be one reason to explain the prevalence of cancer incidence in patients with diabetes mellitus. Research shows that hyperglycemia may contribute to an enhanced proliferation ability, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance.
Mentions: Increasing evidence suggests a close association between diabetes and various malignancies; however, the potential biologic links between the two diseases are incompletely understood. Given that hyperglycemia is the most important biological feature of DM and cancer that are composed of glucose-hungry cells, it is not hard to imagine that hyperglycemia may play an important role during cancer progression in cancer patients with DM. Here, we review the available evidence of the relationship between hyperglycemia and different biological characteristics of cancer. It appears that hyperglycemia may contribute to a more malignant phenotype of cancer cells, including proliferation, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance (Figure 1).

Bottom Line: However, to date, the potential reasons for this association remain unclear.Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected.In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.

ABSTRACT
Recent evidence from large cohort studies suggests that there exists a higher cancer incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for this association remain unclear. Hyperglycemia, the most important feature of diabetes, may be responsible for the excess glucose supply for these glucose-hungry cells, and it contributes to apoptosis resistance, oncogenesis, and tumor cell resistance to chemotherapy. Considering associations between diabetes and malignancies, the effect of hyperglycemia on cancer progression in cancer patients with abnormal blood glucose should not be neglected. In this paper, we describe the role that hyperglycemia plays in cancer progression and treatment and illustrate that hyperglycemia may contribute to a more malignant phenotype of cancer cells and lead to drug resistance. Therefore, controlling hyperglycemia may have important therapeutic implications in cancer patients.

Show MeSH
Related in: MedlinePlus