Limits...
Tissue biomarkers in prognostication of serous ovarian cancer following neoadjuvant chemotherapy.

Khandakar B, Mathur SR, Kumar L, Kumar S, Datta Gupta S, Iyer VK, Kalaivani M - Biomed Res Int (2014)

Bottom Line: Following NACT, significant differences in tumor histomorphology were observed as compared to the native neoplasms.ER expression was associated with poor overall survival.Immunophenotype of SOC does not differ significantly in samples from cases treated with NACT, compared to upfront surgically treated cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

ABSTRACT
Serous ovarian cancer (SOC) is a significant cause of morbidity and mortality in females with poor prognosis because of advanced stage at presentation. Recently, neoadjuvant chemotherapy (NACT) is being used for management of advanced SOC, but role of tissue biomarkers in prognostication following NACT is not well established. The study was conducted on advanced stage SOC patients (n = 100) that were treated either conventionally (n = 50) or with NACT (n = 50), followed by surgery. In order to evaluate the expression of tissue biomarkers (p53, MIB1, estrogen and progesterone receptors, Her-2/neu, E-cadherin, and Bcl2), immunohistochemistry and semiquantitative scoring were done following morphological examination. Following NACT, significant differences in tumor histomorphology were observed as compared to the native neoplasms. MIB 1 was significantly lower in cases treated with NACT and survival outcome was significantly better in cases with low MIB 1. ER expression was associated with poor overall survival. No other marker displayed any significant difference in expression or correlation with survival between the two groups. Immunophenotype of SOC does not differ significantly in samples from cases treated with NACT, compared to upfront surgically treated cases. The proliferating capacity of the residual tumor cells is less, depicted by low mean MIB1 LI. MIB 1 and ER inversely correlate with survival.

Show MeSH

Related in: MedlinePlus

Kaplan-Meier survival analysis curves depicting correlation of survival outcome with treatment (a), age (b), MIB 1 LI (c), mean MIB 1 LI in the neoadjuvant chemotherapy group (d), mean MIB 1 LI in the conventional treatment group (e), and estrogen receptor (f).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4016870&req=5

fig2: Kaplan-Meier survival analysis curves depicting correlation of survival outcome with treatment (a), age (b), MIB 1 LI (c), mean MIB 1 LI in the neoadjuvant chemotherapy group (d), mean MIB 1 LI in the conventional treatment group (e), and estrogen receptor (f).

Mentions: Survival analysis was done for cases with available follow-up data in 62 patients. Thirty patients died during the study period, 12 in NACT group and 18 in US-CT group. Median overall survival of patients in the NACT group was 32 months. For the US-CT group the median overall survival was 29 months (Figure 2(a)).


Tissue biomarkers in prognostication of serous ovarian cancer following neoadjuvant chemotherapy.

Khandakar B, Mathur SR, Kumar L, Kumar S, Datta Gupta S, Iyer VK, Kalaivani M - Biomed Res Int (2014)

Kaplan-Meier survival analysis curves depicting correlation of survival outcome with treatment (a), age (b), MIB 1 LI (c), mean MIB 1 LI in the neoadjuvant chemotherapy group (d), mean MIB 1 LI in the conventional treatment group (e), and estrogen receptor (f).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016870&req=5

fig2: Kaplan-Meier survival analysis curves depicting correlation of survival outcome with treatment (a), age (b), MIB 1 LI (c), mean MIB 1 LI in the neoadjuvant chemotherapy group (d), mean MIB 1 LI in the conventional treatment group (e), and estrogen receptor (f).
Mentions: Survival analysis was done for cases with available follow-up data in 62 patients. Thirty patients died during the study period, 12 in NACT group and 18 in US-CT group. Median overall survival of patients in the NACT group was 32 months. For the US-CT group the median overall survival was 29 months (Figure 2(a)).

Bottom Line: Following NACT, significant differences in tumor histomorphology were observed as compared to the native neoplasms.ER expression was associated with poor overall survival.Immunophenotype of SOC does not differ significantly in samples from cases treated with NACT, compared to upfront surgically treated cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

ABSTRACT
Serous ovarian cancer (SOC) is a significant cause of morbidity and mortality in females with poor prognosis because of advanced stage at presentation. Recently, neoadjuvant chemotherapy (NACT) is being used for management of advanced SOC, but role of tissue biomarkers in prognostication following NACT is not well established. The study was conducted on advanced stage SOC patients (n = 100) that were treated either conventionally (n = 50) or with NACT (n = 50), followed by surgery. In order to evaluate the expression of tissue biomarkers (p53, MIB1, estrogen and progesterone receptors, Her-2/neu, E-cadherin, and Bcl2), immunohistochemistry and semiquantitative scoring were done following morphological examination. Following NACT, significant differences in tumor histomorphology were observed as compared to the native neoplasms. MIB 1 was significantly lower in cases treated with NACT and survival outcome was significantly better in cases with low MIB 1. ER expression was associated with poor overall survival. No other marker displayed any significant difference in expression or correlation with survival between the two groups. Immunophenotype of SOC does not differ significantly in samples from cases treated with NACT, compared to upfront surgically treated cases. The proliferating capacity of the residual tumor cells is less, depicted by low mean MIB1 LI. MIB 1 and ER inversely correlate with survival.

Show MeSH
Related in: MedlinePlus