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Association between two common polymorphisms and risk of hepatocellular carcinoma: evidence from an updated meta-analysis.

Wang Z, Zhang L, Shi X, Xu H, Wang T, Bian J - Biomed Res Int (2014)

Bottom Line: However, the results remain conflicting rather than conclusive.Object.The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China ; Department of General Surgery, The First People's Hospital of Changzhou, Changzhou 213000, China.

ABSTRACT

Background: Recent studies suggested that two common polymorphisms, miR-146a G>C and miR-196a2 C>T, may be associated with individual susceptibility to hepatocellular carcinoma (HCC). However, the results remain conflicting rather than conclusive. Object. The aim of this study was to assess the association between miR-146a G>C and miR-196a2 C>T polymorphisms and the risk of HCC.

Methods: A meta-analysis of 17 studies (10938 cases and 11967 controls) was performed. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association.

Results: For miR-146a G>C, the variant genotypes were associated with a decreased risk of HCC (CC versus GG: OR = 0.780 and 95% CI 0.700-0.869; GC/CC versus GG: OR = 0.865 and 95% CI 0.787-0.952; CC versus GC/GG: OR = 0.835 and 95% CI 0.774-0.901). For miR-196a2 C>T, significant association was also observed (TT versus CC: OR = 0.783, 95% CI: 0.649-0.943, and P = 0.010; CT versus CC: OR = 0.831, 95% CI 0.714-0.967, and P = 0.017; CT/TT versus CC: OR = 0.817, 95% CI 0.703-0.949, and P = 0.008).

Conclusion: The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.

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Related in: MedlinePlus

Begg's funnel plot for publication bias test for mir-146a G>C polymorphism with hepatocellular carcinoma in overall population (a) and in Asian population (b). s.e.: Standard Error; logor: logOR (logarithms of Odds Ratio).
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fig4: Begg's funnel plot for publication bias test for mir-146a G>C polymorphism with hepatocellular carcinoma in overall population (a) and in Asian population (b). s.e.: Standard Error; logor: logOR (logarithms of Odds Ratio).

Mentions: The Begg funnel plot and Egger's test were conducted to assess publication bias. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry in all comparison models (Figure 4). Then, Egger's test was used to provide statistical evidence of funnel plot symmetry. The results still did not show any evidence of publication bias (t = −2.00 and P = 0.074 for miR-146a G>C and t = 1.18 and P = 0.273 for miR-196a2 C>T).


Association between two common polymorphisms and risk of hepatocellular carcinoma: evidence from an updated meta-analysis.

Wang Z, Zhang L, Shi X, Xu H, Wang T, Bian J - Biomed Res Int (2014)

Begg's funnel plot for publication bias test for mir-146a G>C polymorphism with hepatocellular carcinoma in overall population (a) and in Asian population (b). s.e.: Standard Error; logor: logOR (logarithms of Odds Ratio).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4016853&req=5

fig4: Begg's funnel plot for publication bias test for mir-146a G>C polymorphism with hepatocellular carcinoma in overall population (a) and in Asian population (b). s.e.: Standard Error; logor: logOR (logarithms of Odds Ratio).
Mentions: The Begg funnel plot and Egger's test were conducted to assess publication bias. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry in all comparison models (Figure 4). Then, Egger's test was used to provide statistical evidence of funnel plot symmetry. The results still did not show any evidence of publication bias (t = −2.00 and P = 0.074 for miR-146a G>C and t = 1.18 and P = 0.273 for miR-196a2 C>T).

Bottom Line: However, the results remain conflicting rather than conclusive.Object.The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, The Affiliated Nanjing First Hospital with Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China ; Department of General Surgery, The First People's Hospital of Changzhou, Changzhou 213000, China.

ABSTRACT

Background: Recent studies suggested that two common polymorphisms, miR-146a G>C and miR-196a2 C>T, may be associated with individual susceptibility to hepatocellular carcinoma (HCC). However, the results remain conflicting rather than conclusive. Object. The aim of this study was to assess the association between miR-146a G>C and miR-196a2 C>T polymorphisms and the risk of HCC.

Methods: A meta-analysis of 17 studies (10938 cases and 11967 controls) was performed. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association.

Results: For miR-146a G>C, the variant genotypes were associated with a decreased risk of HCC (CC versus GG: OR = 0.780 and 95% CI 0.700-0.869; GC/CC versus GG: OR = 0.865 and 95% CI 0.787-0.952; CC versus GC/GG: OR = 0.835 and 95% CI 0.774-0.901). For miR-196a2 C>T, significant association was also observed (TT versus CC: OR = 0.783, 95% CI: 0.649-0.943, and P = 0.010; CT versus CC: OR = 0.831, 95% CI 0.714-0.967, and P = 0.017; CT/TT versus CC: OR = 0.817, 95% CI 0.703-0.949, and P = 0.008).

Conclusion: The two common polymorphisms miR-146a G>C and miR-196a2 C>T were associated with decreased HCC susceptibility, especially in Asian population.

Show MeSH
Related in: MedlinePlus